Cocarboxylase - instructions for use, analogs, reviews and release forms (injections in ampoules for intravenous and intramuscular injections of hydrochloride) of a drug for the treatment of acidosis and coma in adults, children and pregnancy. Compound. Cocarboxylase, powder

In different syringes and each in its place

both are injected only intramuscularly - there is no need to dilute the solution itself in the butt

and someone needs to unwind their brains! KKB is diluted with a solution! it's powder. drugs in different days inject into the muscle! for example: the first day -kkb, the second -atf

Is it necessary to inject Thiotriazoline and Cocarboxylase in case of diffuse changes in the myocardium?

Good afternoon, dear Victoria Yuryevna! Me long time I was worried about discomfort in the heart area (squeezing, tingling, burning, heart rate increased to 100, the limbs of the arms began to go numb during sleep or in a bent position, and later the legs), after the ECG the therapist said that there was some kind of reflux in the heart, you just need to take some sedatives. 6 months ago I was in a sanatorium and, having done an ECG, they gave me the conclusion “diffuse changes in the myocardium” and advised me to inject ATP and Carboxylase 1 ampoule - 1 time per day for 10 days, to improve metabolism, and after that, inject the same course Thiotriazoline to strengthen the heart muscle, improve oxygen supply, restore heartbeat, and for the prevention of stroke. But, after 1 ampoule, my inflammation worsened trigeminal nerve, but I was told that it was most likely a draft and this drug is not capable of causing such reactions. And so I still pierced for 5 days (5 ampoules), and now, after reading more information, I have doubts whether I need this drug? Thank you in advance for your answer!

Hello. Signs diffuse changes in the myocardium according to ECG data are not a diagnosis, they can occur in various diseases and require clarification of the diagnosis. Regarding appointments, there is nothing wrong with them. Such metabolic therapy is useful both for existing pathology and for prevention. Treatment could not provoke inflammation of the trigeminal nerve. Another thing is that if you have heart disease, this course is not enough, so continue the examination.

"Cocarboxylase": instructions for use, reviews

Many people who have problems with the acid-base balance, in particular those who suffer from diabetes or cardiovascular diseases, are familiar with the drug Cocarboxylase, as it is a vitamin-like drug.

Metabolic acidosis

Over the course of a lifetime, the human body produces a large number of all kinds of acids. He gets rid of their excess through urine, sweating and Airways. This happens if the metabolism is not impaired, because otherwise they will accumulate in the blood and negatively affect the connective and nervous tissues of a person. This process is called metabolic acidosis and often it manifests itself when the body suffers from a lack of vitamin B1. This pathology entails dangerous consequences: increased coagulability blood, myocardial infarction, peripheral thrombosis, hyperglycemic coma and death. For this reason, specialists who discover problems with the acid-base balance in a patient prescribe pharmacological agent"Cocarboxylase". Instructions for use are presented below.

Pharmacological abilities

Cocarboxylase is a non-protein organic enzyme that is directly involved in the neuro-reflex processes of the body, reducing the amount of lactic, pyruvic and alpha-ketoglutaric acids.

Its positive actions are aimed at carbohydrate metabolism and providing tissues with energy. Cocarboxylase deficiency leads to deterioration in glucose absorption, cardiac muscle function, and nerve tissue metabolism. This can lead to a person being susceptible to diseases such as acidosis, diabetes mellitus, neurocircular dystonia, heart pathologies, etc. In turn, the drug “Cocarboxylase” normalizes acid-base and energy metabolism. This, in turn, promotes antitoxic and anti-ischemic effects.

"Cocarboxylase": instructions for use and indications

The drug is prescribed to a patient who needs to stabilize metabolism during respiratory, hepatic, cardiovascular and renal failure. Ischemic heart diseases, pre- and post-infarction conditions that may arise due to high level acidity in the blood, the coenzyme drug “Cocarboxylase”, analogues of which are also able to combat similar problems, helps to normalize the human condition. It is often prescribed to people suffering from chronic alcoholism and any form of poisoning, including medication.

The drug "Cocarboxylase", the instructions for use of which are below, is also prescribed for infectious diseases:

Peripheral neuritis and multiple sclerosis are also no exception. Even in pediatric practice, the medicine has found its place. It is used during pregnancy if there is severe toxicosis or fetal hypoxia.

“Cocarboxylase” are ampoules with powder that will be used for injection to the patient. For children medicine administered intramuscularly, subcutaneously, or in some cases sublingually under the tongue. The drug "Cocarboxylase" is used intravenously only for adults once a day.

Children of any age under eight years of age are administered 25 mg of Cocarboxylase. Instructions for use for adults and children after eight years of age are slightly different - mg. The duration of drug treatment is determined by the doctor individually for each patient. It all depends on the degree and neglect of the disease.

"Cocarboxylase": indications during pregnancy

The fetus is completely in the body healthy woman, gets everything essential vitamins and microelements for normal development. But if a pregnant woman experiences serious complications, such as severe toxicosis in the last months of pregnancy, eclampsia, impaired transport of thiamine, convulsions, then “Cocarboxylase” is prescribed to the expectant mother before it is installed the real reason the appearance of this or that disease. The drug is also approved for use by pregnant women suffering from diabetes mellitus.

Side effects and contraindications

There are practically no side effects from the use of the drug, with the exception of intolerance to the active substance itself (cocarboxylase). Instructions for use focus on the fact that after administration this tool, no serious side effects were noted.

Cocarboxylase is very effective drug, but before using it in treatment, you should mandatory consult your doctor.

"Cocarboxylase-Forte" - what is it and how is it different?

Many people, having fallen ill with one or another disease, visit pharmacies and ask to be given something that works, but without the need for injections. There is nothing strange about this, because an injection is always an additional and unwanted expense. In addition, this is very inconvenient, since not everyone can home environment give yourself an injection or ask your relatives about it. After all, if you do it wrong, then discomfort and discomfort in the injection area are guaranteed. Therefore, the drug “Cocarboxylase-Forte” in tablets was created.

Cocarboxylase is not the only component that is part of the drug. It also contains glycerol amino acids and magnesium ions. They significantly improve the activity of cocarboxylase. Magnesium helps improve absorption and metabolism, and glycerin provides a mild effect, improving and normalizing sleep.

The drug "Cocarboxylase", reviews of which are very positive, does not differ much from "Cocarboxylase-Forte" in terms of pharmacological actions. It is also successfully used in cases of violation acid-base balance and for the prevention of complications in diabetes mellitus.

"Cocarboxylase-Forte": clinical trials

Experts assure that Cocarboxylase-Forte is very effective for use in complex therapy in patients suffering from diabetes, coronary heart disease, dystonia, and metabolic processes, as well as to prevent the development of complications in the cardiovascular system.

"Cocarboxylase-Forte": advantages

This drug is this moment are more often purchased than “Cocarboxylase” for injection, due to the advantages of use without discomfort and the absence of additional costs in the form of syringes, water for injection, etc.

This is especially important for children who suffer from the above diseases. After all, the fact that they have been exposed to such an illness already causes them a lot of trouble, and it is very important to provide them with at least comfortable treatment without the use of needles.

Method of use of the drug and its contraindications

"Cocarboxylase-Forte" is not prescribed to those people who have increased sensitivity to the components. It is also not recommended for pregnant women. The drug is not prescribed to children under twelve years of age.

Diabetic patients taking Cocarboxylase-Forte should monitor their blood sugar levels daily.

The dosage is always determined by the attending physician. Adults and children over the age of twelve take one tablet under the tongue until completely dissolved, 3-4 times a day. It is also intended to be administered orally 15 minutes before meals 3-4 times a day; the tablet should be taken with a small amount of water. The course of treatment usually lasts no more than a month.

Side effects of Cocarboxylase-Forte

According to experts, the drug is well tolerated by the body. Side effects that may occur are associated either with an overdose or with individual intolerance to the components. Possible manifestations of hives, rash, redness of the skin, itching, nausea and headaches. If you feel these symptoms, you should contact your doctor, who will, if possible, reduce the dosage or give you the opportunity to use another drug if reducing the amount of Cacorboxylase-Forte does not help get rid of the discomfort.

One way or another, no matter what drug you choose, before purchasing it you should consult your doctor and discuss with him all the issues that may concern you.

If there is a need to purchase Cocarboxylase for a child, then check the possibility of using the drug without using injections, if this is provided for in your case and the age of your child allows it. Pregnant women should also be especially careful when using the drug in any form.

"Cocarboxylase": indications for use

The use of Cocarboxylase reduces the concentration of pyruvic and lactic acid, improves glucose processing, has a positive effect on the trophism of nerve tissue, and normalizes the functionality of the cardiovascular system. If the body is deficient in this substance, the level of pyruvic acid in the blood increases, which can lead to the development of acidosis.

Release form and composition

Indications for use and price

average price cocarboxylase in ampoules and bottles. You can buy cocarboxylase in pharmacies.

Application of cocarboxylase and indications:

• Diabetic, metabolic, respiratory acidosis (disturbances in the acid-base state, they manifest themselves as low rate blood pH levels and bicarbonate concentrations are below normal.
• Hypoglycemia, hyperglycemia (high and low level Sahara).
• Pathological processes occurring in the body, accompanied by disorders of carbohydrate metabolism. Diseases in this group can be hereditary or acquired. The most common are galactosemia, generalized glycogenosis, and diabetes mellitus.
• Hepatic, respiratory, renal, heart failure. Relevant for acute and chronic form diseases.
• Post-infarction cardiosclerosis - as a component complex treatment cordially vascular diseases, more details at the link).
• Hepatic coma.
• Diabetic coma. (Very often occurs in diabetes mellitus as a result of abnormal blood sugar levels)
• Chronic alcoholism and acute poisoning alcohol.
• Poisoning with drugs from the barbiturate group, digitalis.
• Paratyphoid fever, scarlet fever, diphtheria, typhus - as a component of complex therapy.
• Multiple sclerosis, peripheral neuropathy.
• Perinatal hypoxic encephalopathy, pneumonia, sepsis, respiratory failure in newborns.
• Conditions accompanied by acidosis and hypoxia.

Instructions for use and dosage

Instructions for the use of cocarboxylase injections and powders for preparing the solution:

• The drug Cocarboxylase is administered subcutaneously, intramuscularly or intravenously. The dose of the drug is prescribed individually, based on medical history, the patient’s condition and the severity of the disease.
• For adults, the drug is administered once - 50/100 mg. If necessary, as in the case of a diabetic coma, once every two to three hours. In the future, the prescribed therapy is maintained - 50 mg daily.
• For stable circulatory failure - strictly 50 mg two to three times daily, before taking digitalis medications. The course of procedures is one day.
• For diabetes mellitus – mg daily for 5-10 days, without stopping standard antidiabetic therapy.
• At acute form renal or liver failure, burns, intoxications xmg three times a day.
• For multiple sclerosis and peripheral neuritis, 50/100 mg daily.

Contraindications

• High sensitivity to the drug.
• Hypovitaminosis Vitamin B1.
• Vitamin deficiency Vitamin B1.

During pregnancy and children

For children, the drug is administered intramuscularly or subcutaneously, except for newborns. They administer the drug sublingually.

Cocarboxylase hydrochloride intramuscular good support for the heart

Today I felt inspired to write reviews about medications. It’s already night outside, but I still can’t stop))).

This time, I’ll tell you about a drug that helped me restore my heart and maintain my body’s strength after childbirth. When you're on your feet around the clock, postpartum depression, and then there are two kids at once, it’s very difficult for my motor. Therefore, when arrhythmia began and my body began to tremble from lack of sleep (especially nightly pumping milk), I asked my mother to give me injections of Cocarboxylase hydrochloride intramuscularly.

Fortunately, my mother is a doctor and for injections, I don’t have to go to the hospital.

My course of treatment was simple: for one day I was injected with the drug ATP (also to support the heart).

On the second day, Cocarboxylase hydrochloride was injected.

By alternating these drugs, my heart received a kind of “vitamins” that gave me the strength to take care of my children around the clock.

The package contains 10 bottles of cocarboxylase + 10 bottles of solvents for intramuscular injection.

Unfortunately, I can’t show photos of ATF, since those injections are over. And my mother bought another package of cocarboxylase. I will show part of the instructions for use in the photo. But it clearly states that if you have heart problems and poor carbohydrate metabolism, you can inject this drug. At that time I already had tachycardia, since I had not slept normally for almost half a year. And my husband didn’t help either. I have laid out the method of using this drug sequentially. For those interested, you can read how to dilute injections before use.

My course of treatment to restore the heart rhythm and improve its functioning was 20 days.

10 days ATP drug + 10 days cocarboxylase drug.

The injections are very painful, especially cocarboxylase. It feels like a bee stung me. At the end of the treatment, I was already crying from the injections.

But how my heart began to work later. Like new! The arrhythmia and tachycardia went away, I felt a surge of strength and energy. I don't regret going through all this. Even the circles under the eyes are gone))).

The price of the drug for 10 ampoules is 70 hryvnia, or 300 rubles.

The entire course of treatment cost me 150 hryvnia (including ATP).

Cocarboxylase - solution for injection

Many pharmaceutical companies they are bringing to market the medicine Cocarboxylase, which belongs to the simple B vitamins. Each ampoule contains 0.05 grams of the main component. The package also contains an additional ampoule with a solution for diluting the powder. The drug is available in powder for injection, which will be dissolved before direct administration. The package contains 5 or 10 ampoules.

Pharmacological properties

This product provides next action on the body:

• coenzyme;
• takes part together with sodium and proteins in accelerating carboxylation and decarboxylation;
• accelerates the formation of acetyl-coenzyme A, which helps normalize carbohydrate metabolism.

Pharmacodynamics

At parenteral administration the drug component is quickly and completely absorbed mainly in the small intestine and duodenum. Only 11 hours after use, cocarboxylase is eliminated from the body. During the study of the drug, it was possible to find out that it is found in all tissues, and is especially abundant in the liver, heart and brain.

Cocarboxylase helps glucose to be absorbed and the cardiovascular organs to function normally. Also, the main component helps improve tissue nutrition. Its lack provokes the accumulation of acids, and acidosis develops and its consequence is acidotic coma. Cocarboxylase is most often recommended in the presence of pathologies during which endogenous deficiency is observed.

Pharmacokinetics

When it enters the bloodstream, the main component of the drug is picked up by red blood cells and distributed throughout the body in the form of thiamine diphosphate. Metabolic processes occur in the liver, and the drug is excreted through the kidneys in the urine.

Indications

Doctors prescribe Cocarboxylase if the patient has the following diseases:

• diabetic, metabolic and respiratory acidosis;
• heart failure;
• impairment of kidney function;
• breathing problems;
• cardiosclerosis that occurred after a heart attack;
• disruption of carbohydrate metabolism;
• heart attack;
• unstable angina;
• coronary heart disease, which occurs in a chronic form;
• diabetic and hepatic coma;
• acute alcohol poisoning and its consequences;
• a history of chronic alcoholism;
• multiple sclerosis;
• various infectious diseases;
• sepsis followed by hypoxia and acidosis.

Contraindications

The only contraindication to the use of the drug is the presence of an allergic reaction to its main or auxiliary components.

Side effects

During clinical studies, it was found that Cocarboxylase can provoke the appearance of negative reactions when using a dose that exceeds 0.5 grams per day. Patients complain of the development of such sensations:

• loss of appetite;
• pain in the stomach area;
• be sick;
• anxiety and fear appear;
• sleep is disturbed;
• rash, hives and itching occur on the skin.

When the drug is administered intramuscularly, the following may develop: adverse reactions, which are local in nature:

Dosage

The instructions describe the following methods of administering the drug:

Only a doctor has the right to prescribe the dose, frequency of administration and course of therapy, which depends on the health status of each individual patient.

The average dose for an adult is 1-2 ampoules per day. The doctor may decide to administer the drug with a break that does not exceed just a few hours. Most often this happens when the patient is diagnosed with a diabetic coma, and after the condition improves, it is enough to use 50 milligrams per day.

Circulatory disorders

Dose of Cocarboxylase for this disease: 1 ampoule up to 3 times a day. The duration of therapy can range from 14 days to 1 month.

Diabetes

Patients with this pathology must be administered the drug at a dose of 100–1000 milligrams per day for up to 10 days without a break. Along with this, it is necessary to take other medications for diabetes.

In the presence of acute renal and liver failure in the first few days, Cocarboxylase is administered into a vein, 1-3 ampoules 3 times a day. You can also use the drug by drip. To do this, dissolve the required mg of the drug in 400 ml of a 5% glucose solution.

Neuritis

For this disease, the medicine is administered intramuscularly, 1-2 ampoules per day. The course of treatment ranges from 30 to 45 days.

For children

Children who have not reached 3 months of age can be administered 25 mg of Cocarboxylase subcutaneously or intramuscularly. Patients from 3 months to 7 years are prescribed mg per day, and from 8 to 18 years mg can be used.

Pregnant

If the doctor takes responsibility and decides to prescribe Cocarboxylase to a pregnant woman, then it is diluted with glucose and vitamin C and administered intravenously. The duration of therapy ranges from 10 days to two months. The main indications for use of the drug during this period are:

Overdose

If you exceed the dose prescribed by your doctor, the following symptoms may appear:

• heart rate increases;
• be sick;
• gagging;
• headache;
• feeling weak and overworked;
• muscles spasm;
• the functioning of the cardiovascular system is disrupted;
• sweating increases;
• shortness of breath and allergic reactions appear.

If one or more symptoms develop, you must stop administering the drug and contact your doctor. medical institution, where doctors can provide first aid and provide symptomatic treatment for an overdose.

Drug interactions

Cocarboxylase is very actively combined with various medications and biologically active substances. Let's look at the main interactions:

1. With antidepressants, activity increases.
2. B vitamins contribute to the activation of therapeutic effects.
3. Digoxin - provokes a decrease in the ability of the myocardiocyte to absorb the active substance and its metabolites.

It is forbidden to combine Cocarboxylase with drugs that have an alkaline or neutral reaction.

Features of application

During complex treatment of any disease, it is worth considering the ability of the main component to activate the cardiotonic activity of drugs from the group of cardiac glycosides. In the presence of atrial fibrillation intravenous administration of the drug is prohibited.

During pregnancy

For ethical reasons clinical researches No studies have been conducted on the effect of cocarboxylase on pregnant, lactating women and their babies. For this reason, it is not recommended to use this drug during this period.

Reaction

How Cocarboxylase affects the reaction rate while driving a car or working with other mechanisms is unknown, because manufacturers have not studied this issue.

Acquisition

You can buy Cocarboxylase in injections if you provide a prescription from your doctor, which will indicate the required dose and course of treatment.

Storage

To save therapeutic effect you must adhere to the following rules:

• the temperature in the room where the medicine is located should not exceed 25 degrees;
• humidity must be kept low;
• ampoules should be kept away from children and direct sunlight.

The expiration date is indicated on the packaging and should not exceed 36 months. After this period has expired, the ampoules must be disposed of.

Analogues

Instructions for the use of Cocarboxylase injections indicate the presence of the following analogues:

Price

The cost of the drug directly depends on the manufacturer of the drug and the retail outlet. The average price for 5 ampoules of Cocarboxylase is 50 rubles, which makes the medicine accessible to different segments of the population.

Cocarboxylase - instructions for use, analogs, reviews and release forms (injections in ampoules for intravenous and intramuscular injections of hydrochloride) of a drug for the treatment of acidosis and coma in adults, children and pregnancy. Compound

In this article you can read the instructions for use of the drug Cocarboxylase. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Cocarboxylase in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications were observed and side effects, perhaps not stated by the manufacturer in the annotation. Analogues of Cocarboxylase in the presence of existing structural analogues. Use for the treatment of acidosis, diabetic coma and liver and kidney failure in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Cocarboxylase is a coenzyme formed in the body from thiamine. Has a metabolic effect, activates tissue metabolism. In the body it is phosphorylated to form mono-, di- and triphosphoric esters; cocarboxylase is part of enzymes that catalyze the carboxylation and decarboxylation of keto acids, pyruvic acid, and promotes the formation of acetyl coenzyme A, which determines its participation in carbohydrate metabolism. Participation in the pentose cycle indirectly promotes the synthesis of nucleic acids, proteins and lipids.

Improves the absorption of glucose, trophism of nervous tissue, and helps normalize the functions of the cardiovascular system.

Cocarboxylase deficiency causes an increase in the level of pyruvic and lactic acids in the blood, which leads to acidosis and acidotic coma.

Cocarboxylase hydrochloride + excipients.

• metabolic acidosis;
• hyperglycemic coma and acidosis in diabetes mellitus;
• liver failure;
• renal failure;
• respiratory acidosis in chronic, cardiopulmonary failure;
• respiratory failure;
• chronic circulatory failure;
• myocardial infarction and post-infarction cardiosclerosis (as part of complex therapy);
• acute alcohol poisoning;
• chronic alcoholism;
• poisoning with digitalis preparations, barbiturates;
• intoxication with infectious diseases: diphtheria, scarlet fever, typhus and paratyphoid fever (in complex therapy);
• peripheral neuritis.

In children during the neonatal period:

• perinatal hypoxic encephalopathy;
• respiratory failure;
• pneumonia;
• sepsis;
• hypoxia;
• acidosis.

Lyophilisate for the preparation of a solution for intravenous and intramuscular administration (injections in injection ampoules).

Others dosage forms, be it pills or suppositories, does not exist.

Instructions for use and usage diagram

Adults are administered intramuscularly or intravenously. The dose is mg per day. Diabetes mellitus (acidosis, coma) daily dose may be 0.1-1 g. The frequency and duration of use depends on the indications.

For children - intramuscularly, intravenously (drip (dropper) or stream), for newborns - sublingually. Children up to 3 months - 25 mg per day, from 4 months to 7 years, mg per day, from 8 to 18 years, mg per day. The duration of treatment is from 3-7 to 15 days.

• allergic reactions (urticaria, itching);
• hyperemia, itching and swelling at the injection site.

• hypersensitivity to cocarboxylase.

Use during pregnancy and breastfeeding

No medical studies have yet been conducted on the effectiveness and safety of using cocarboxylase during pregnancy. Therefore, there is no reliable data on the contraindication of cocarboxylase at this time. A doctor's consultation is required.

Application is possible according to the dosage regimen.

Enhances the cardiotonic effect of cardiac glycosides and improves their tolerability.

Analogues of the drug Cocarboxylase

Structural analogues of the active substance:

• Cocarboxylase Improv;
• Cocarboxylase Ferein;
• Cocarboxylase Ellara;
• Cocarboxylase hydrochloride.

Analogues pharmacological group(medicines for the treatment of acidosis):

• Alpha D3 Teva;
• Dimephosphone;
• Kalinor;
• Quintasol;
• Sodium bicarbonate;
• Compound sodium lactate;
• Stylamine;
• Trometamol N.

Cocarboxylase

Description current as of 01/27/2015

• Latin name: Cocarboxylase
• ATX code: A11DA01
• Active ingredient: Cocarboxylase (Cocarboxylase)
• Manufacturer: Microgen NPO Federal State Unitary Enterprise, DEKO company, Moskhimfarmpreparaty im. N.A. Semashko (Russia), Jelfa S.A. (Poland)

Compound

One ampoule with lyophilisate for preparing a solution includes cocarboxylase hydrochloride 50 mg and solvent (sodium acetate solution) 2 ml.

Release form

The powder from which the injection solution is prepared, supplied in 50 ml ampoules, quantity - 5 pieces in one package.

pharmachologic effect

Cocarboxylase has a coenzyme effect, as it is a coenzyme of thiamine. In combination with protein and magnesium ions, it catalyzes the carboxylation and decarboxylation of alpha-keto acids, and also stimulates the formation of acetyl-coenzyme A, thereby normalizing carbohydrate metabolism.

Pharmacodynamics and Pharmacokinetics

Cocarboxylase is characterized by rapid and absolute absorption when administered parenterally. Absorption occurs mainly in the small intestine and duodenum. Clearance - approximately 11 hours. The active substance of the drug almost completely penetrates into all tissues, but its highest concentration is observed in the liver, kidneys, brain and heart.

Transportation in the blood occurs with the help of red blood cells, which contain about 80% total number cocarboxylase in the form of thiamine diphosphate. Metabolism active substance carried out in the liver. The drug is excreted from the body in the urine in an amount depending on the dose taken.

Cocarboxylasum is the active form of vitamin B1, which has a metabolic effect by activating tissue metabolism. Phosphorylates in the body, forming mono-, di- and triphosphoric esters. This substance belongs to the group of enzymes that catalyze the carboxylation and decarboxylation of keto acids, pyruvic acid, and also stimulates the formation of acetyl coenzyme A, due to which it participates in carbohydrate metabolism.

The drug promotes the absorption of glucose and normalizes the functions of the cardiovascular system. In addition, the substance improves tissue trophism, and with its deficiency, an increase in the content of pyruvic acid and lactic acid in the blood occurs, which can provoke the development of acidosis and ultimately lead to acidotic coma.

This drug is prescribed for diseases accompanied by endogenous cocarboxylase deficiency in combination with B vitamin.

Indications for use of Cocarboxylase

The described drug is prescribed for:

Contraindications

Individual intolerance to the active substance.

Side effects

Cocarboxylase has side effects on the body after administration of a dose exceeding 500 mg per day. Side effects occur in the form of the following reactions:

Side effects may also occur in the area where the drug is administered in the form of:

Instructions for use of Cocarboxylase

This drug is administered in three ways:

The dosage is prescribed by the doctor individually, depending on the patient’s disease and his current condition.

Cocarboxylase, instructions for use

The dosage of the drug depends on the indications for use of Cocarboxylase. Adults are prescribed a milligram of the drug per day intramuscularly. At the discretion of the physician, the dose may be repeated at intervals of two hours. Typically this dose increases with diabetic coma with a further transition to maintenance therapy with a dosage of 50 milligrams per day.

For patients with circulatory insufficiency, the drug is prescribed to be taken at a dosage of 50 milligrams per day with a frequency of two or three times. The course of treatment can range from two weeks to one month.

For patients with diabetes mellitus, the drug is prescribed intravenously in a dosage of 100 to 1000 milligrams per day for five to ten days. In this case, conventional antidiabetic therapy does not stop.

For patients with acute liver and kidney failure, the drug is prescribed intravenously in a dosage of 50 milligrams to 150 milligrams three times a day, or the drug is prescribed drip in a dosage of 100 to 300 milligrams per day with preliminary dissolution in 400 milligrams of a 5% glucose solution.

Patients with peripheral neuritis are prescribed this drug in a dosage of 50 to 100 milligrams per day intramuscularly. The duration of treatment can be 1-1.5 months.

For children under three months of age, the medicine is prescribed subcutaneously or intramuscular injections dosage: 25 milligrams per day. For children over 3 months and up to 7 years, the drug is administered in a dosage of 25 to 50 milligrams per day. For children from 8 to 18 years of age, the medicine is administered in a dose of 50 to 100 milligrams per day.

Cocarboxylase during pregnancy is prescribed in a course of 10 days, 50 milligrams per day. The powder dissolves in twenty milligrams of glucose. The injection is given intravenously in combination with ascorbic acid in the form of a solution.

During pregnancy, Cocarboxylase is prescribed for fetal hypoxia, as well as in conjunction with complex therapy in the treatment of toxicosis.

Overdose

If the dose prescribed by the doctor is exceeded, symptoms of overdose may appear in the form of:

If symptoms of overdose occur, the drug is discontinued and mandatory symptomatic treatment is carried out.

Interaction with other drugs

Cocarboxylase interacts effectively with a number of medicines and biologically active substances:

• antidepressants in combination with the drug - increased effect;
• B vitamins – with simultaneous administration this drug enhances the effect of vitamins;
• digoxin – the ability of myocardiocytes to absorb the active substance of the drug and its metabolites decreases;
• the use of this drug in combination with solutions with an alkaline or neutral reaction is not recommended.

Terms of sale

The drug is sold in pharmacies only with a doctor's prescription.

Storage conditions

The drug can be stored at a temperature not exceeding 25C Celsius in a dry place protected from direct sunlight.

Best before date

The shelf life of the drug is 3 years. It is not recommended to use the medicine after the expiration date.

Cocarboxylase analogues

• Cocarboxylase Improv - is a coenzyme that is formed in the body from thiamine;
• Cocarboxylase Ferein is a complete analogue of the described drug, which has an identical effect on the body;
• Cocarboxylase Ellara;
• Cocarboxylase Hydrochloride is a coenzyme of enzymes involved in carbohydrate metabolism.

Thank you

Substances included in the group of vitamin B 1 (thiamine) have an active effect on the functioning of the body, participating in metabolism and neuro-reflex reactions. They are able to provide positive influence for various diseases, and therefore are considered as medicines.

Dosage form

Properties and action

Cocarboxylase is endogenously synthesized from vitamin B1 and is a coenzyme. Coenzymes (coenzymes) are components of enzymes - proteins that serve as catalysts for all biochemical reactions. The functions of coenzymes are usually performed by vitamins. Cocarboxylase is a coenzyme of enzymes that regulate saccharide metabolism. In combination with protein and magnesium ions, it is integral part carboxylase enzyme, which serves as a regulator of saccharide metabolism, prevents the accumulation of lactic and pyruvic acids in the body, and stimulates the absorption of glucose. All this contributes to more efficient energy production, which means improved metabolism throughout the body.

Thiamine, entering the body, is first broken down into cocarboxylase, and only in this form does it take part in metabolic processes. Thus, cocarboxylase is the active form of coenzyme obtained from thiamine during its endogenous breakdown. However biochemical properties thiamine pyrophosphate are not identical to the properties of thiamine, therefore, cocarboxylase is not used in the treatment of diseases caused by vitamin B1 deficiency. It is used in complex therapy for various pathological conditions, requiring stabilization of carbohydrate metabolism.

Thiamine pyrophosphate promotes the absorption of glucose, normalizes metabolism in nervous tissue, and restores the functions of the heart muscle. A lack of cocarboxylase leads to an imbalance in the acid-base balance of the blood (acidosis), which leads to severe pathologies of all organs and systems, and can lead to coma and death.

The effectiveness of cocarboxylase has been proven by many clinical studies.

Indications and contraindications

• with acidosis that has developed due to metabolic disorders during various pathologies, for example, during a diabetic crisis (fainting due to high concentration blood glucose);
• for respiratory and heart failure, incl. in newborns;
• for chronic cardiovascular failure;
• with ischemic heart disease, incl. pre-infarction conditions, myocardial infarction, post-infarction conditions;
• in cases of impaired liver and kidney function;
• with alcohol abuse;
• for toxicosis caused by certain medications (glycosides, barbiturates);
• at infectious diseases(diphtheria, typhus, etc.);
• for pathologies nervous system(pain and inflammatory reactions peripheral nerves, multiple sclerosis, etc.);
• for brain pathologies in newborns caused by hypoxia;
• for any conditions characterized by impaired saccharide metabolism.

Thiamine pyrophosphate is contraindicated for use in case of individual intolerance.
It is recommended to obtain medical advice before using the drug.

Side effects and symptoms of overdose

If the acid-base balance in the body is disturbed, acidosis can occur. This serious pathology associated with human metabolic problems. Its consequences may include renal, hepatic, and respiratory failure. To rid a person of the problem of acidification of the body, special coenzyme preparations are used, for example, the drug Cocarboxylase.

Instructions for use of Cocarboxylase

In Latin, the name of the drug sounds like Cocarboxylase, the medication is produced by domestic and foreign manufacturers, and has been known for a long time. The active component of the drug is cocarboxylase hydrochloride, which has coenzyme properties, eliminates the manifestations of acidosis and returns the human body to normal functioning.

Composition and release form

The drug is known only in the format of a lyophilisate - powder for preparation parenteral solution. Composition and description:

Pharmacological properties

Cocarboxylase is a coenzyme ( organic compound, which plays an important role in the reactions) thiamine (vitamin B1). In combination with proteins and magnesium ions, it catalyzes (accelerates) the process of carboxylation and decarboxylation of alpha-keto acids and stimulates the formation of acetyl-coenzyme A. This leads to the normalization of carbohydrate metabolism.

The active substance of the drug is quickly and completely absorbed when administered parenterally. Absorption of the component occurs in the small intestine and duodenum; the substance is excreted after 11 hours. The drug is found in the liver, brain, kidneys, and heart. Red blood cells carry active ingredient medications in the form of thiamine diphosphate. Metabolism of the component occurs in the liver, metabolites are excreted in the urine.

The metabolic effect of the drug occurs due to the activation of tissue metabolism. Cocarboxylase powder is phosphorylated to form phosphorus esters, promotes the rapid absorption of glucose and normalizes the functioning of the cardiovascular system. Also, the active component of the composition improves tissue trophism; with a lack of substance, the level of pyruvic and lactic acids in the blood increases, which leads to the development of acidosis and acidotic coma.

Indications for use

The drug is prescribed for diseases associated with endogenous coenzyme deficiency in combination with B vitamins. Indications are:

• metabolic, diabetic, respiratory acidosis;
• cardiac, renal, respiratory failure;
• post-infarction cardiosclerosis;
• disorders of carbohydrate metabolism due to pathological processes;
• myocardial infarction;
• unstable angina;
• chronic ischemic heart disease;
• hepatic, diabetic coma;
• acute alcohol poisoning, chronic alcoholism;
• multiple sclerosis;
• sepsis, pneumonia;
• diseases accompanied by hypoxia and acidosis;
• infectious diseases.

Directions for use and dosage

The drug can be administered subcutaneously, intramuscularly or intravenously. For adults, 50-100 mg/day is indicated; according to the doctor’s decision, a second dose is administered after two hours. For diabetic coma, the maintenance dosage is 50 milligrams/day. In case of circulatory failure, 50 mg of dissolved substance is administered 2-3 times/day for a course of 2-4 weeks. Patients with diabetes mellitus receive intravenous drips of 100-1000 mg/day for a course of 5-10 days against the background of usual antidiabetic therapy.

For acute liver and kidney failure, Cocarboxylase is administered intravenously at a dosage of 50-150 mg three times a day, or 100-300 mg/day drip in 400 ml of a 5% glucose solution. For peripheral neuritis, 50-100 mg/day intramuscularly for up to 45 days helps. Newborns up to three months receive intramuscular or subcutaneous injections solution at a dose of 25 mg/day. Up to seven years, 25-50 mg/day is administered, from 8 to 18 years – 50-100 mg/day.

special instructions

Cocarboxylase contains glycocholic acid, which, when administered repeatedly or for a long time to patients with jaundice or cholestasis, can impair liver function. Others special instructions to the drug:

1. After dilution of the lyophilisate, the solution can be stored longer than a day at a temperature of 2-8 degrees, and it is better to use it immediately.
2. It is unknown how the drug affects speed and concentration, because the patients receiving treatment were in moderate and severe serious condition and were physically unable to operate vehicles and machinery.

Cocarboxylase during pregnancy

Indications for the use of the drug during pregnancy include fetal hypoxia and treatment of toxicosis as part of complex therapy. Pregnant women are prescribed a course of medication for 10 days at 50 mg/day. The lyophilisate is dissolved with 20 ml of glucose, injections are given intravenously in combination with the solution ascorbic acid(vitamin C).

Drug interactions

1. Antidepressants enhance the effect of Cocarboxylase.
2. The drug enhances the effect of B vitamins when used simultaneously.
3. Digoxin reduces the ability of myocardiocytes to absorb the active substance of the drug and its metabolites.

Side effects

The development of negative reactions to the drug is possible after administration of a dose of over 500 mg/day. TO side effects means include:

• lack of appetite, stomach pain, nausea, atony;
• feelings of anxiety, fear, sleep disturbances;
• ataxia (loss of coordination), lethargy;
• acute respiratory failure;
• allergic reactions: urticaria, itching, skin rash;
• swelling, pain, severe burning at the injection site.

Overdose

If you exceed the prescribed dosage of the drug, you may develop tachycardia, vomiting and nausea, headache, weakness and general fatigue. A person may experience muscle spasms, shortness of breath, increased sweating, allergic reactions occur and the functioning of the cardiovascular system is disrupted. If signs of overdose appear, treatment with the drug is canceled and symptomatic therapy.

Cocarboxylase contraindications

The drug is used with caution during pregnancy and lactation ( breastfeeding). Contraindications for its use are hypersensitivity, individual intolerance or allergy to the constituent components of the medication or its active ingredient. active substance. In this case, the drug is replaced safe analogue.

Terms of sale and storage

You can buy the medicine only with a prescription. The drug is stored at temperatures up to 25 degrees in a dry, dark place without access to sunlight for three years from the date of manufacture.