Why is magnesium B6 prescribed to adults? Application of "Magnesium B6", reviews of the drug. Daily requirement for magnesium

The drug contains a combination of magnesium and vitamin B6. Renders positive influence on nervous system, reduces irritability, improves the conduction of nerve impulses, and normalizes sleep. Can be used from 6 years of age. Approved for use during pregnancy, where the drug not only normalizes the psycho-emotional state of a woman, but also replenishes the deficiency of magnesium and vitamin B6.

Dosage form

Magnesium B6 is available in the form of tablets of 30 or 50 pieces per package. There are different packaging options - 30 and 50 tablets. Tablets are biconvex, oval, white.

Description and composition

Magne B6 tablets are one of effective means, used for adults, children and pregnant women. The drug can be used for a variety of conditions of the body, diseases of the central nervous system. This tool has a positive effect on metabolic processes, increases immunity, improves sleep, heart function, and liver function. Reviews about the drug are quite good. Many note that after taking the drug their condition improved, increased anxiety and irritability disappeared, sleep improved, and they managed to cope with depressive disorders.

The drug contains:

  • magnesium lactate 2-water;
  • vitamin B6 (hydrochloride);
  • Excipients.

Pharmacological group

Magne B6 – medicinal product with high efficiency, which fulfills the lack of magnesium in the body. Basically, a person receives magnesium through food, but when the diet is unbalanced, the need for it increases. Most often, magnesium deficiency occurs during pregnancy, with increased mental stress and stress. The use of the drug allows you to fulfill magnesium deficiency, has a positive effect on bones, muscle structure, internal organs and systems. The instructions for the drug indicate that taking Magnesium B6 tablets allows you to provide next action on the body:

  • maintains cholesterol levels;
  • regulates phosphorus metabolism;
  • participation in neuromuscular excitation;
  • improves the functioning of the heart muscle;
  • takes part in fat, protein and carbohydrate metabolism;
  • has a neuroprotective effect;
  • synthesizes enzymes;
  • stimulates the production of blood cells.

Thanks to the unique composition of the drug, its use allows, improves the functioning of the whole organism, eliminates pathological processes, reduce the risk of developing serious diseases.

Indications for use

Indications for the use of the drug are considered to be various dysfunctions of the central nervous system, which manifest themselves against the background of magnesium deficiency in the body.

For adults

  • sleep disturbance;
  • increased fatigue;
  • physical or mental fatigue;
  • increased irritability;
  • muscle pain and spasms;
  • feeling of anxiety.

For children

Children can take Magnesium B6 from 6 years of age with the following disorders:

  • increased nervous excitability;
  • sleep problems;
  • unreasonable fears and worries;
  • mental stress;
  • acidosis.

Especially useful drug considered for women during pregnancy. Taking the drug allows you to protect the nervous system, fulfill the deficiency useful components. Magnesium is extremely important for a pregnant woman, since its lack can lead to the development. The following complaints may be indications for prescribing the drug:

  • mood swings;
  • increased irritability;
  • insomnia;
  • increased fatigue;
  • severe toxicosis;
  • risk of miscarriage;
  • calf muscle cramps;
  • hair loss.

Magnesium can be prescribed at any stage of pregnancy, but its use must be agreed with your doctor.

Contraindications

The drug has several contraindications for use:

  • intolerance to the components of the drug;
  • children under 6 years old;
  • fructose intolerance;
  • glucose-galactose deficiency syndrome.

With caution, the drug should be prescribed for diseases of the kidneys, liver, and also with other vitamins, especially those that contain a daily dose of magnesium and thiamine. This use increases the risk of side effects.

Applications and dosages

The instructions for use contain standard doses of the drug, but the doctor must prescribe it individually for each patient.

For adults

The drug tablets must be taken with sufficient quantity water. The daily dose for an adult is 6 – 8 tablets. The therapeutic course is 30 days.

For children

Children over 6 years old are prescribed 1 tablet twice a day. The tablets must be swallowed whole, but if the child has difficulty swallowing the tablet, it can be crushed and mixed with a small amount of water.

For pregnant women and during lactation

During pregnancy daily dose The drug should not exceed 4 - 6 tablets. The dose should be determined by the doctor based on general condition pregnant woman.

Side effects

Magnesium B6 is well tolerated, but in some exceptions, symptoms may occur after taking the medication. adverse reactions body:

  • skin rashes;
  • bronchospasm;
  • nausea;
  • abdominal pain;
  • stool disorder;

Adverse reactions after taking the drug are very rare, but if they develop, you should stop taking the drug as soon as possible and consult a doctor. The doctor may be able to stop taking the drug or reduce the dose of the drug.

Interaction with other drugs

Taking Magne B6 reduces the absorption of tetracycline antibiotics, so when taking them, the interval should be at least 3 hours.

special instructions

  • Take the drug with caution since the outer shell of the tablet contains sucrose.
  • The tablets are intended only for adults and children over 6 years of age.
  • Before taking the medicine, you should study the instructions for use.
  • Children under 6 years of age are recommended to take other forms of the drug: injections, suspension.
  • It is prohibited to exceed the daily dose of the drug.
  • Do not take the drug without preliminary consultation with a doctor.
  • If after 2 weeks of taking the medicine there are no positive results from the treatment, tell your doctor.

Overdose

In the practice of doctors, cases of overdose have not been recorded, but it is still important to follow the prescribed dosage of the medication. With increasing doses of the medicine, disturbances in the functioning of the stomach may appear, nausea may appear. In some cases, allergic skin reactions may occur.

Storage conditions

The drug should be stored out of the reach of children and direct sunlight should be avoided. You can buy the medicine without a doctor's prescription.

Analogs

Instead of Magnesium B 6 you can use the following medications:

  1. is a complete analogue of the drug Magnesium B6. It is produced in tablets that can be used in patients over 6 years of age, including during pregnancy. It is not advisable to take the medicine during lactation.
  2. Magnistad is a medicine from the Shtad company, which is a complete analogue of Magnesium B6. It is produced in enteric-coated tablets. They can be used to treat patients over 6 years of age, including pregnant patients. Magnesium is excreted through the mammary glands, so the medicine is not recommended for breastfeeding women.
  3. Magnesium plus B6 is a complete analogue of the drug Magnesium B6. The medicine is produced by Valenta Pharmaceuticals PJSC, Russia. Both drugs are similar, have similar indications and limitations, causing the same side effects.
  4. Magnesium Plus is a combined medication containing magnesium carbonate and lactate, cyanocobalamin, and folic acid as active ingredients. It is on sale in effervescent tablets. They are allowed to be drunk by persons over 6 years of age, including during pregnancy.

Drug price

The cost of the medicine is on average 238 rubles. Prices range from 107 to 405 rubles.

Every child needs many vitamins and microelements. Most useful substances he gets from . Sometimes necessary additional dose one or another element in the form medical product. In what cases and at what age should Magnesium B6 be used for children? Let's try to figure it out.

Importance of Magnesium for Health

Magnesium is a vital substance for humans. He is one of the seven most necessary for the body minerals along with calcium and phosphorus. Contained in the blood and all cells, and maximum concentration observed in teeth and bone tissues. Magnesium is involved in a huge number metabolic processes.

It is very important to maintain a sufficient level of this element in children. Magnesium deficiency is associated with the occurrence of large quantity diseases of the nervous and cardiovascular systems.

Main functions of magnesium:

  • conduction of nerve impulses
  • contractions of the muscles of the heart and intestines
  • normalizes the state of the nervous system
  • decrease in intracranial pressure
  • stimulation of insulin production
  • acceleration of metabolism
  • bone formation
  • regulation of enzyme activity

In children, the lack of this mineral is due to its low intake from food and frequent stressful situations. may have many reasons: adaptation to new conditions, starting to attend kindergarten or school, family discord, moving, age-related changes, hormonal changes. All this does not pass without a trace and results in repeated hysterics, tearfulness, anxiety attacks and restless sleep.

Magnesium B6 for children is often used necessary drug. Its peculiarity is that it contains organic magnesium salts. They are absorbed much better (35-50%), while the digestibility of inorganic salts is only from 5 to 20%. Additionally, the drug is enriched with vitamin B6, which promotes more efficient absorption of the mineral by the intestines and penetration into the body’s cells.

By replenishing a child's magnesium deficiency, parents notice better academic performance. Children's behavior becomes calmer and their attention increases.

The main thing is to observe moderation and not give medications without reason and agreement with the pediatrician.

Symptoms of magnesium deficiency in children

According to research, in modern world about 33% of people suffer from magnesium deficiency. Even from food, only 30-50% is absorbed. The absorption of the element is impaired by the consumption of large quantities of animal fats, diuretic products, calcium, soda, and sausages. Children also experience decreased absorption of magnesium due to prolonged or prolonged bouts of vomiting.

Magnesium deficiency affects general health, the functioning of the cardiovascular and nervous systems, symptoms in children are as follows:

  • lethargy, fatigue
  • headaches, in the heart and abdomen
  • nervous tics (eyelid twitching), shuddering
  • deterioration of skin, nails and hair
  • arrhythmia, tachycardia
  • high or low blood pressure
  • weather sensitivity
  • reduced
  • leg muscle cramps
  • irritability, withdrawal, panic attacks, increased excitability
  • restless sleep, frequent waking up at night
  • memory impairment

Magnesium B6 is especially recommended for children during stressful situations, such as adaptation to kindergarten or new class, moving. The product will help increase the stability of the nervous system when needed. After all, it is not always possible to obtain the required amount of an element from food.

According to the theory of V.A. Tutelyan, a scientific figure in, daily need in magnesium in children is as follows:

  • up to one year – 30-70 mg
  • 1 -3 years – 60-150 mg
  • 4-6 years – 200 mg
  • 7-10 years – 250 mg
  • from 10 years – 300 mg

Parents may immediately notice some symptoms of magnesium deficiency in their child. More details about what a magnesium deficiency threatens the body can be seen in the video:

However, you should not rush to conclusions and panic. A qualified specialist will help dispel doubts and prescribe treatment.

How and in what dosage to give Manium B6 to children

Naturally, if parents have a question: at what age can Magnesium B6 be used for children? The annotation for the drug states that the drug in the form of a solution can be given from the age of one year, and in tablets – from the age of 6 years. This age limit is due to a lack of clinical trials.

In practice, neurologists often prescribe this drug to young patients in the first year of life and note positive results treatment. For such children, medication should be prescribed only according to indications.

The dosage of the medicine is determined based on the extent of magnesium deficiency in the body. Thus, children older than one year and who have gained 10 kg of weight or more are prescribed Magnesium B6 in the form of a solution from 1 to 4 ampoules per day. Each ampoule contains 100 mg of the mineral. The tablets are recommended for children over 6 years of age and who have gained 20 kg of weight. The dosage is from 4 to 6 tablets daily.

The course of treatment usually takes 1 month. If necessary, treatment is repeated after 3-6 months.

  • the daily dose should be evenly distributed over 2-3 doses
  • Magnesium B6 should be given in the morning and lunchtime, no later than 4 pm
  • Do not take the medicine with milk
  • should not be given simultaneously with calcium and phosphate supplements

Every mother wants the best for her baby. But do not forget that you cannot prescribe medications yourself. This is especially true for young children.

If you take Magnesium B6, you should inform your doctor about this, since the drug passes into the milk.

Contraindications and caution

Magnesium B6 has some contraindications:

  • serious deficiency
  • fructose intolerance and sucrase-isomaltase deficiency (tablets contain sucrose)
  • individual intolerance to components
  • glucose-galactose malabsorption (impaired absorption of carbohydrates)
  • taking levodopa
  • phenylketonuria (disorder of amino acid metabolism)

In most cases, the drug is well tolerated by children. Mostly Negative consequences occur in cases of overdose, especially if the child has problems with kidney function.

Symptoms of overdose may be the following:

  • low pressure
  • diarrhea and vomiting
  • confusion
  • breathing disorder
  • decreased urinary output
  • slowness, decreased activity

With anyone pharmacological agent an inexperienced person needs to be careful. The most common cases of magnesium overdose occur when parents prescribe it independently. Therefore, experts strongly do not recommend taking any medications “just in case.” A doctor should diagnose magnesium deficiency and prescribe the required dose.

Compound Active ingredients:

  • magnesium lactate dihydrate* - 186 mg;
  • magnesium pidolate* - 936 mg;
  • pyridoxine hydrochloride - 10 mg;

Excipients:

  • sodium disulfite - 15 mg,
  • sodium saccharinate - 15 mg,
  • cherry-caramel flavoring - 0.3 ml,
  • purified water up to 10 ml.

* - equivalent to a total magnesium content (Mg++) of 100 mg.

Description Clear liquid Brown with the smell of caramel.
Pharmacological properties

Pharmacodynamics

Magnesium is vital important element, which is found in all tissues of the body and is necessary for the normal functioning of cells, is involved in most metabolic reactions. In particular, it is involved in the regulation of the transmission of nerve impulses and muscle contraction. The body receives magnesium through food. A lack of magnesium in the body can occur when the diet is disrupted or when the need for magnesium increases (with increased physical and mental stress, stress, pregnancy, use of diuretics).

Pyridoxine (vitamin B6) is involved in many metabolic processes and in the regulation of nervous system metabolism. Vitamin B6 improves the absorption of magnesium from the gastrointestinal tract intestinal tract and its penetration into cells.

Serum magnesium levels:
  • from 12 to 17 mg/l (0.5 – 0.7 mmol/l) - moderate magnesium deficiency;
  • below 12 mg/l (0.5 mmol/l) - severe magnesium deficiency.
Pharmacokinetics

Absorption of magnesium in the gastrointestinal tract is no more than 50% of the dose taken orally. 99% of magnesium in the body is found inside cells. Approximately 2/3 of intracellular magnesium is distributed in bone tissue, 1/3 is in smooth and striated muscle tissue. Magnesium is excreted primarily in the urine (at least 1/3 of the administered dose of magnesium).

Indications for use

Indications for use

Established magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as:

  • increased irritability,
  • minor sleep disorders,
  • gastrointestinal spasms,
  • cardiopalmus,
  • increased fatigue,
  • pain and muscle spasms,
  • tingling sensation in the muscles.
Contraindications

Contraindications

Carefully

  • With moderate degree renal failure, since there is a risk of developing hypermagnesemia.

Use during pregnancy and lactation

Pregnancy

Breastfeeding period

Magnesium penetrates into breast milk. The use of the drug should be avoided during lactation and breastfeeding.

Directions for use and doses

Directions for use and doses

Before taking the drug, you should consult your doctor.

The drug can be used for children from 1 year of age.

For children over 1 year of age (body weight more than 10 kg), the daily dose is 10-30 mg magnesium/kg body weight (0.4 - 1.2 mmol magnesium/kg) or 1-4 ampoules.

The daily dose should be divided into 2-3 doses, taken with meals.

The solution from the ampoules is dissolved in ½ glass of water before use.

Treatment should be stopped immediately after normalization of magnesium concentration in the blood.

ATTENTION

Magne B6 ® ampoules do not require the use of a nail file. To open the ampoule, take it by the tip, having previously covered it with a piece of cloth, and break it off with a sharp movement, first from one pointed end and then from the other, having previously directed the end of the ampoule that opened first at an angle into a glass of water, so that the one being broken off by the second the tip of the ampoule was not above the glass. After breaking off the second tip of the ampoule, its contents will flow freely into the glass.

Side effect

Side effect

According to the World Health Organization (WHO), adverse effects are classified according to their frequency as follows: very common (≥ 1/10), common (≥ 1/100,

Violations by immune system:

Very rarely: allergic reactions. Frequency unknown: skin reactions (urticaria, itching), severe allergic reactions, including bronchospasm

Gastrointestinal disorders:

Frequency unknown: diarrhea, abdominal pain.

Overdose

Overdose

Symptoms

With normal renal function, an overdose of magnesium when taken orally usually does not lead to toxic reactions. However, in case of renal failure, magnesium poisoning may develop.

Symptoms of overdose, the severity of which depends on the concentration of magnesium in the blood: decrease blood pressure; nausea, vomiting; depression of the central nervous system, decreased reflexes; changes in the electrocardiogram; respiratory depression, coma, cardiac arrest and respiratory paralysis; anuric syndrome.

Treatment

Rehydration, forced diuresis. In case of renal failure, hemodialysis or peritoneal dialysis is necessary.

Interaction with other drugs

Interaction with other drugs

Contraindicated combinations

  • With levodopa: the activity of levodopa is inhibited by pyridoxine (unless this drug is combined with the use of peripheral aromatic L-amino acid decarboxylase inhibitors). Any amount of pyridoxine should be avoided unless levodopa is taken in combination with peripheral aromatic L-amino acid decarboxylase inhibitors.
  • The simultaneous use of drugs containing phosphates or calcium salts may impair the absorption of magnesium in the intestine.

Combinations to Consider

  • When prescribing tetracyclines orally, it is necessary to maintain an interval of at least three hours between ingestion of tetracycline and Magne B6, since magnesium preparations reduce the absorption of tetracyclines.
special instructions

special instructions

In case of severe magnesium deficiency or malabsorption syndrome, treatment begins with intravenous administration magnesium preparations.

In case of concomitant calcium deficiency, it is recommended to correct the magnesium deficiency before taking calcium supplements or food additives containing calcium.

With frequent use of laxatives, alcohol, intense physical and mental stress, the need for magnesium increases, which can lead to the development of magnesium deficiency in the body.

The oral solution contains sulfite, which may cause or intensify allergic reactions, including anaphylactic reactions, especially in high-risk patients.

When using pyridoxine in high doses (more than 200 mg per day) for a long time (over several months or in some cases years), sensory axonal neuropathy may develop, which is accompanied by symptoms such as numbness, impaired proprioceptive sensitivity, distal tremor limbs and gradually developing sensory ataxia (impaired coordination of movements). These disorders are usually reversible and disappear after stopping taking vitamin B6.

For the body to function correctly, it is simply necessary that it be provided with all vitamins and minerals, and in the proper quantities. Both a state of deficiency of one or another component, as well as its excess, is dangerous, so this issue must be approached very carefully and wisely. Many elements are absorbed and act more effectively in certain combinations, on the basis of which many drugs are created. For heart function, a complex of vitamin B6 and magnesium is simply indispensable, which are combined in one preparation for ease of use. All details of its application and an overview of the main manufacturers will be discussed in this article.

The benefits of magnesium B6 for the body

The drug magnesium-B6 very quickly and effectively improves the condition of the body due to its numerous beneficial properties. Magnesium as a mineral has the following types of effects on the human body:

  • magnesium deficiency – common reason the occurrence of heart diseases, since this mineral is simply necessary for the correct functioning of the heart muscle;
  • regulates metabolic processes;
  • normalizes the processes of transmission of nerve impulses;
  • helps prevent the development of atherosclerosis;
  • minimizes the risk of complications in diabetes;
  • Magnesium deficiency may cause increased irritability and anxiety, so taking
  • This drug helps to keep nervous tension under control.

Vitamin B6, which is part of the drug, is intended to enhance the function of the drug - it promotes more efficient absorption of the component from digestive system and its penetration into cellular elements. In addition, this vitamin also has a positive effect on the nervous system and metabolic processes. In general, this drug is simply irreplaceable in a number of diseases and pathological conditions.

Release form Magne-B6

The drug Magne-B6 is available in two pharmacological forms:

  • a liquid solution in ampoules, brownish in color with a characteristic caramel aroma, which must be taken orally;
  • tablets in different options packages (30 and 50 pieces), there are also effervescent tablets.

For ease of use, ampoules with a substance usually do not need to be filed with anything, since they are self-breaking - you just need to firmly grasp the thin tip and gently press it over the glass - this way the contents of the ampoule will fall into the glass without any difficulties.

It is worth noting that the contents of one ampoule are equivalent to 100 mg of magnesium, and one tablet is on average about 50 mg, which determines different volumes of the drug depending on the chosen pharmacological form.

Why is magnesium B6 prescribed: indications for use

The drug Magnesium-B6 is prescribed for use if there is a shortage of this element in the body, as well as to eliminate those problems that were caused by this deficiency. Thus, the following problems are considered indications for use:

  • increased nervous excitability;
  • irritability;
  • anxiety attacks;
  • periodic tingling sensation in the body;
  • severe fatigue;
  • the presence of spasmodic pain in the muscles;
  • cardiopalmus.

For children

The drug in tablet form can be given to children from 6 years of age, and in the form of a solution - from one year. Exactly how much of the substance will be prescribed to the baby depends on his condition and the magnitude of the existing deficiency of the component in the body. It must be borne in mind that such a supplement can be given to children only after permission from a doctor.

During pregnancy

If a woman has heart problems, then while carrying a baby she simply needs to take magnesium supplements to maintain and stabilize her condition. Also in this delicate time magnesium B6 can be prescribed by a doctor for increased tone uterus and cramps, since such conditions threaten the baby, and magnesium helps relieve muscle tension.

For men

B-group vitamins and magnesium preparations are very useful for the stronger half of humanity. Taking magnesium B6 helps not only normalize energy metabolism, but also improve the nervous system, prevent the development of many dangerous processes in the liver and increase the level of testosterone production.

Instructions for use of the product and dosage

To avoid the appearance side effects and achievements maximum benefit from taking the described drug, it is extremely important to strictly follow all the recommendations given by the manufacturer in the instructions. The dosage relative to the patient's age is of particular importance.

How to take pills correctly

It is best to take tablets during meals or immediately after the next meal and wash them down with plenty of liquid (best - clean water). Depending on the specific production of the drug, there can be from one to three doses per day.

Consider the standard dosage of the drug Magnesium B6:

  • for adults (including children over the age of twelve), in case of deficiency, 6 to 8 tablets are prescribed, and to eliminate spasms - 4-5 tablets;
  • The tablet form is possible for use by children over 6 years of age, and the standard dosage is from 2 to 5 tablets per day, depending on the complexity of the condition.

The average course of treatment with the drug is usually a month.

How to dilute the product in ampoules and drink the solution

To prepare the solution, dilute one ampoule of the substance in half a glass warm water. This mixture should be drunk with meals - the number of doses per day depends on age and body weight. For example, for an adult, the optimal volume is 3-4 ampoules during the day. For children over one year of age, with a body weight not exceeding 10 kilograms, the optimal dose will be from one to three ampoules. Average general rate therapeutic measures is about one month.

Review of the best preparations containing magnesium and vitamin B6

The combination of magnesium and vitamin B6 is very effective in a number of cases, so it is often prescribed. There is the most famous drug of this group - Magne-B6, but in addition to it there are a number of analogues that will cost less, but provide similar action: Magnelis B6, biologically active additive from Blagomax, etc. We invite you to familiarize yourself with the list the best drugs, based on a powerful combination of pyridoxine and magnesium.

Magne B6 forte

The tableted product has the form of biconvex film-coated tablets. If you break one of them, then two layers will be clearly visible at the break - the white shell and the mass itself active substance inside. No additional active substances There are none in the composition, but several auxiliary ones are intended to provide storage conditions and comfortable reception by patients and do not have any effect. These tablets are usually prescribed for children over 6 years of age and for adults as a monthly course, but these criteria may vary depending on the specific situation.

Evalar

The drug from Evalar is a combined complex. The action is based on a combination of B6 and magnesium salt, which has the greatest bioavailability. For achievement daily norm an adult needs to take 6 tablets (2 tablets three times a day, which provides about 70% of the body's needs, the remainder is covered by food consumed). The product is available in large purple packages in two versions - 36 or 60 tablets. It is worth noting that the need to take a sufficiently large number of tablets during the day makes it advisable to purchase a large package.

Antistress

The Antistress complex contains B-group vitamins and minerals, including magnesium. Taking the drug helps to inhibit the processes of nervous excitation, thereby reducing the degree of a person’s susceptibility to external influences. The drug is produced in France, which makes it quite high cost compared with Russian analogues. Available in packs of 60 tablets, 15 pieces in one blister. The drug can be used even for children infancy if necessary, but only in the form of a solution.

Vitamins Doppelherz aktiv (Doppelherz asset)

The complex from Doppelherz called Magnesium B6 contains the following active components among its ingredients:

  • vitamin B6;
  • magnesium;
  • folic acid.

It is used as an additional source of vitamins, magnesium and folic acid, which allows you to create normal conditions for the functioning of the body. Taking tablets is very simple - just one tablet per day during and after meals, preferably in the first half of the day for better absorption. One package contains 30 tablets, which are packaged in blisters of 10 pieces.

Harm and side effects from using the medicine

Compliance with the recommendations described in the instructions for the drug reduces the likelihood of side effects to a minimum. Under certain circumstances, they can still occur and manifest themselves as a short-term disorder of the digestive system (constipation, active gas formation, nausea, and in rare cases - loose stool) or as allergy symptoms in case of intolerance to certain components of the product consumed.

An overdose of magnesium as a component is a situation that is quite difficult to achieve, since its excess is usually easily excreted by the kidneys. However, if this drug is used by a person with kidney failure, a number of toxic reactions may occur:

  • a noticeable decrease in the reflex activity of the body;
  • feeling of nausea and vomiting;
  • general depression of psychological state;
  • decrease in pressure;
  • respiratory dysfunction;
  • in difficult cases - cardiac arrest or coma.

Contraindications

There are a number of situations in which the use this drug is prohibited. These include the following pathological conditions and diseases:

  • renal failure;
  • hypersensitivity to components;
  • diabetes (if the excipients of the tablets include sucrose);
  • period of taking laxatives;
  • increased physical activity;
  • abuse of alcoholic beverages.

Separately, it is worth noting that during pregnancy, magnesium-B6 is often prescribed to women to normalize their condition, since it does not have any adverse effects. But when breastfeeding It is better to avoid such a drug, as it passes into breast milk and can cause an excess of certain substances in the baby’s body.

Analogues of the drug Magne-B6

The combination of magnesium and vitamin B6 is quite popular due to its effectiveness, so finding a substitute with more affordable price or a convenient dosage will not be difficult. It is worth paying attention to the following drugs:

  • Magwit;
  • Beresh Magnesium Plus;
  • Magnefar B6;
  • Magnelis B6;
  • Magnicum, etc.

The key to a successful reception result similar drugs– this means the presence of specific indications and strict adherence to the rules of administration and dosage.

(pyridoxine hydrochloride) - 5 mg.

Heavy kaolin, carboxypolymethylene, sucrose, magnesium in the form of hydrosilicate (talc) and stearate, and acacia gum are used as auxiliary components.

Shell composition pills: acacia gum, sucrose, titanium dioxide, trace amounts of hydrous magnesium silicate and carnauba wax in powder form.

Part solution for oral administration includes 186 mg of magnesium lactate dihydrate and 936 mg of magnesium pidolate (which corresponds to a total Mg++ content of 100 mg), 10 mg of pyridoxine hydrochloride.

Auxiliary components: sodium disulfite and saccharinate, cherry and caramel flavoring, purified water.

Compound Magnesium B6 Forte tablets (Antistress): 618.43 mg magnesium citrate, 10 mg pyridoxine hydrochloride, anhydrous lactose, magnesium stearate and hydrosilicate, macrogol 6000, hypromellose, titanium dioxide.

Release form

Pharmacological forms of the drug:

  • biconvex oval pills in a white film shell with a shiny smooth surface (10 pieces in blisters of aluminum foil and PVC, 5 blisters per package);
  • transparent, brown solution for oral administration with a pronounced caramel smell (in ampoules of 10 ml, 10 ampoules in a cardboard packaging insert);
  • white oval biconvex pills in a film shell (15 pieces in blisters made of aluminum foil and PVC-PE-PVDC, 2 or 4 blisters per package).

pharmachologic effect

Pharmacotherapeutic group: B vitamins in combination with minerals. The action of the drug is aimed at replenishing magnesium deficiency.

Pharmacodynamics and pharmacokinetics

Magnesium (Mg) - this is an important biogenic element, which is present in significant quantities in all tissues of the body, is a cofactor of most metabolic processes and ensures normal cell functioning.

In particular, this element is necessary for biotransformation creatine phosphate in ATP - nucleoside triphosphate, which plays the role of a universal energy supplier in living cells of the body.

Without magnesium it cannot be synthesized normally protein . The element takes part in muscle contraction (including supporting normal function heart muscle ), regulates the transmission of impulses in nerve fibers , promotes expansion vessels , stimulates bile separation , increases motor activity intestinal tract , which in turn promotes excretion from the body.

Magnesium enters the body with food. Its deficiency can be primary (due to hereditary pathologies) or secondary. Secondary magnesium deficiency is usually associated with:

  • with eating disorders (poor vitamins and minerals diet, exclusively parenteral nutrition, chronic alcoholism);
  • with an increase in a person’s need for a microelement during intense physical or mental activity, during periods of intense growth, during pregnancy, during stress, excessive losses of Mg through the kidneys (for example, with chronic , abuse diuretics , treatment);
  • with impaired absorption of Mg in the gastrointestinal tract due to Gipoparathyroidism , chronic diarrhea etc..

Vitamin B6 (pyridoxine) improves the course of metabolic processes, including in brain tissue. As a result, brain performance increases, mood and memory improve.

Moreover, the presence pyridoxine as part of the drug Magne B 6 improves the absorption of Mg from digestive tract and its distribution in the cells of the body.

If the serum concentration of Mg is in the range from 12 to 17 mg/l, they speak of moderate Mg deficiency. An indicator not exceeding 12 mg/l is evidence of severe microelement deficiency.

IN digestive tract no more than half of the Mg dose taken orally is absorbed. 99% of the trace element is located in the intracellular space, while about 66% of intracellular Mg is distributed in bone tissue , the remaining amount is in striated and smooth muscles .

Mg is excreted mainly in the urine (about a third of the dose taken).

Indications for use

Indications for use of the drug Magne B6 are: confirmed Mg deficiency (both isolated and associated with other deficiency conditions).

Symptoms that Mg is entering the body in insufficient quantities are increased fatigue and irritability, sleep disturbances, rapid heartbeat, stomach and intestinal cramps, tingling sensation in the muscles, as well as their spasticity and soreness.

Contraindications

Contraindications to the use of Magne b6 are:

  • severe renal failure (conditions in which clearance does not exceed 30 ml per minute);
  • impaired absorption of glucose and galactose , fructose intolerance, sucrose-isomaltase deficiency (only for the tablet form of the drug);
  • simultaneous administration antiparkinsonian drug ;
  • hypersensitivity to the substances contained in the tablets/solution.

In pediatrics, tablet forms of the drug are prescribed from the age of six; the solution in ampoules is allowed from the age of one.

Due to the risk of developing hypermagnesemia the drug should be prescribed with caution to persons with moderate degree renal failure .

Side effects

The drug very rarely causes side effects. Allergic (including skin) reactions are possible in no more than 0.01% of cases.

Sometimes taking Magne B 6 is accompanied by side effects from digestive tract (flatulence, abdominal pain, diarrhea, nausea, vomiting), however, it is impossible to determine the frequency of their occurrence based on currently available data.

Instructions for Magna B6

Before taking Magne B6, you should consult your doctor. The average course duration is one month. Treatment is stopped immediately after the Mg concentration in the blood is normalized.

The medicine is taken with meals 2 or 3 times a day.

If the drug is prescribed during pregnancy, the dose is selected individually by the attending physician.

Magne B6 tablets: instructions for use

Magne b6 tablets are taken 6-8 pieces per day.

According to the instructions for use for children, the daily dose for patients over 6 years of age (provided that their body weight exceeds 20 kg) is 4 to 6 tablets.

Instructions for Magne B6 in ampoules

Adults are prescribed the solution to take 3-4 ampoules of 10 ml per day. Before administration, the drug is dissolved in 0.5 glasses of drinking water.

For children over 12 months (if their body weight exceeds 10 kg), Magne B6 in ampoules is prescribed to take 10-30 mg of Mg per kilogram of weight (the indicated dose is contained in 1-4 ampoules of the drug).

Instructions for Magne B6 Premium

The tablets are taken with meals. Swallow them whole with a glass of drinking water.

For an adult, the daily dose of Magne B 6 is 3-4 tablets. Children over six years of age (if their weight exceeds 20 kg) should be given 10 to 30 mg/kg/day. (or 2-4 tablets).

Overdose

In patients with normally functioning kidneys, magnesium overdose with orally usually does not provoke toxic reactions. At renal failure Excess magnesium can cause poisoning, the symptoms of which are:

  • nausea;
  • vomit;
  • ECG changes;
  • decrease in blood pressure;
  • hyporeflexia ;
  • CNS depression;
  • cardiorespiratory dysfunction (up to coma, respiratory paralysis and cardiac arrest);
  • anuric syndrome .

The severity of overdose symptoms depends on the concentration of the trace element in the blood.

Treatment involves forced diuresis and purpose rehydration therapy . At renal failure shown peritoneal dialysis And .

Interaction

Due to pyridoxine (in any quantity) inhibits activity levodopa , it is contraindicated to prescribe this drug in combination with Magne B6. This applies to situations where the reception levodopa is not combined with taking drugs that suppress the activity of peripheral decarboxylase of aromatic amino acids existing in the L-form.

Since Mg preparations reduce absorption tetracyclines , between taking them you should maintain at least a three-hour interval.

Terms of sale

Over the counter.

Storage conditions

Magne B6 No. 50: in a place protected from moisture and light, out of reach of children, where the temperature is maintained at up to 25 degrees Celsius.

Solution: in a place protected from light at temperatures up to 25 degrees Celsius.

Magne B6 Forte: at temperatures up to 30 degrees Celsius. Keep away from children.

Best before date

The tablets are usable for 24 months and the solution for 36 months after the date of manufacture.

special instructions

Ampoules with Magne B6 solution are self-breaking (each has 2 marking rings and a break line) and does not require the use of a nail file.

To open the ampoule, take it by the tip, having previously covered it with a piece of fabric, and with a sharp movement break it off first from the pointed end, then from the opposite. Opened first the end is directed at an angle into a cup of water so that the tip of the ampoule, which is broken off second, is not above the cup.

After the second tip of the ampoule is broken off, the solution will flow freely into the glass.

Patients with need to remember that the composition of film-coated tablets as excipient sucrose is present. Therefore, it is more preferable for them dosage form is a solution that does not contain sugar.

At malabsorption syndrome (impaired absorption) and severe magnesium deficiency, treatment should begin with intravenous administration of Mg preparations.

If a patient has a concomitant calcium deficiency, the Mg deficiency is corrected before taking dietary supplements or medications that contain Ca.

The solution contains sulfite, a substance that can cause or intensify hypersensitivity reactions, including anaphylactic type reactions (especially in patients at risk).

Taking high (exceeding 200 mg/day) doses pyridoxine within a few months/years may cause the development sensory axonal polyneuropathy , which is manifested by symptoms such as tremor, numbness and disorders of proprioceptive sensitivity of the distal parts of the arms and legs, gradually manifesting sensory ataxia (impaired balance).

Disorders of this kind are usually reversible and disappear after stopping taking vitamins.

Analogues of Magne B6

Level 4 ATX code matches:

Analogues of Magne B6 are drugs Magnesium B6 Evalar , Magnelis B6 , , Magnistad , AT 6 , Beresh Magnesium plus B6 .

The price of analogue tablets is from 150 Russian rubles.

Which is better: Magnelis or Magne B6?

A drug Magnelis B6 is produced by Pharmstandard and, like its analog Magne B6, is intended to replenish Mg deficiency in organism. The products have a similar composition (Magnelis contains 470 mg of Mg lactate and 5 mg pyridoxine , in Magna B6 - 470 mg Mg lactate dihydrate and 5 mg pyridoxine ), identical indications for use and contraindications, cause similar side effects.

The main differences are the manufacturer and price.

Magne B6 for children

Magnesium is very important for children because it participates in various biochemical reactions of the body, improves the absorption of calcium and the tone of the walls of blood vessels, and normalizes the conduction of nerve impulses in the brain.

Magnesium deficiency is very closely related to stress. Experts consider Mg deficiency and stress to be interdependent processes that can aggravate each other.

AND spicy , And chronic stress lead to depletion of the intracellular Mg pool and its loss in the urine. This is due to the fact that in stressful situation the body secretes more and, which contribute to the elimination of Mg from cells.

Magnesium deficiency often leads to decreased ability to concentrate, memory impairment, seizures , disturbance of consciousness and coordination sphere (usually this manifests itself in the form nystagmus, ataxia, tremor ). Some children develop paresthesia and rise tendon reflexes .

In children of all ages, Mg deficiency (as well as stress) provokes an increase in - one of the significant components of stress and changes the cerebroreactive reactivity of blood vessels towards a constrictor response.

Biochemical and clinical-neuropsychological studies, as well as reviews of Magne B6 for children, confirm that taking Mg drugs can curb the rise in blood pressure, increase stress resistance, improve behavior, memory and attention, normalize sleep, reduce anxiety, synkinesis and aggression.

In accordance with the instructions, in pediatric practice the solution is prescribed from the age of one year, tablets - after 6 years, however, in the presence of neurological disorders, Magne B6 can be used from the first days of life. Dosage infant calculated depending on his body weight.

It is very important that the composition of the drug (both in the form of a solution and in the form of tablets) includes organic Mg salts - lactate, citrate and pidolate - which are characterized by high bioavailability and practically do not cause side effects.

Magne B6 Forte, which is based on Mg citrate, is recommended for use in children with oxalaturia and acidosis , as well as in children with a lateral shift: the drug is used to compensate for rapid nervous and mental exhaustion in patients with neuroarthritic type of constitution and for prevention urolithiasis .

Magne B6 during pregnancy

Why Magne B6 during pregnancy?

Magne b6 is prescribed quite often during pregnancy. It is advisable to use the drug in pregnant women when:

  • threatening spontaneous miscarriage hypertonicity of the uterine muscles ;
  • confirmed by test results Mg deficiency in organism.

Clinical experience with the use of Mg preparations and doctors’ reviews of Magne B6 indicate that the prescription of the drug for hypertonicity of the uterus allows you to quickly and effectively calm the nervous system, as well as relieve spasms and tension in the muscles.

The main reason for the increased tone of the uterine muscles is the calcium contained in the muscle fibers. Mg has the ability to reduce its amount and thereby promote muscle relaxation.

During the period of bearing a child female body more magnesium is required than usual. If the microelement is not supplied to it from the outside in the required doses, the fetus begins to draw Mg from the mother’s body, which significantly affects the health and well-being of the pregnant woman. Once the mother's Mg reserves are depleted, the condition of the fetus will also begin to deteriorate.

Magnesium deficiency causes poor development of blood vessels in the placenta, which leads to malnutrition of the fetus and the threat of miscarriage.

Contraindications

The instructions for the drug indicate that contraindications for its use are fructose intolerance , severe renal failure , allergic reactions to the substances contained in the tablets/solution.

How to take MagneB6 during pregnancy?

The dosage of Magne B6 during pregnancy is usually as follows: 2 tablets with each of the main meals (morning, lunch and evening). Thus, the dose of Magne B 6 for a pregnant woman is 6 tablets per day, and the dosage regimen does not change depending on the stage of pregnancy.

In the 1st and 2nd trimesters, the use of the drug is advisable if there is a threat of miscarriage. In the third trimester, a woman usually experiences an increased feeling of discomfort, night cramps and swelling.

Magnesium deficiency can lead to increased secretion aldosterone and the development of edema. Delayed excretion of fluid from the body, in turn, provokes increased blood pressure , which is very dangerous both during pregnancy and during childbirth.

The duration of treatment can range from 2 weeks to 9 months. After childbirth, the drug is stopped, since it tends to penetrate into the milk of a nursing woman.

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