Magnesium b6 is prescribed for adults. Application of "Magnesium B6", reviews of the drug. Daily need for magnesium

The product contains a combination of magnesium and vitamin B6. Renders positive influence on nervous system, reduces irritability, improves the conduction of nerve impulses, normalizes sleep. Can be used from 6 years of age. Approved for use during pregnancy, where the drug not only normalizes the psychoemotional state of a woman, but also compensates for the deficiency of magnesium and vitamin B6.

Dosage form

Magnesium B6 is available in the form of tablets, 30 or 50 pieces per pack. There are different packaging options - 30 and 50 tablets each. Tablets are biconvex, oval, white.

Description and composition

Magne B6 tablets are one of effective means used for adults, children and pregnant women. The drug can be used for a variety of conditions of the body, diseases of the central nervous system. This remedy has a positive effect on metabolic processes, increases immunity, improves sleep, heart and liver function. Reviews of the drug are quite good. Many people note that after taking the drug, their condition improved, increased anxiety and irritability disappeared, sleep improved, and they managed to cope with depressive disorders.

The preparation contains:

• magnesium lactate 2-water;
• vitamin B6 (hydrochloride);
• Excipients.

Pharmacological group

Magne B6 - medicinal product with high efficiency, which fulfills the lack of magnesium in the body. Basically, a person receives magnesium with food, but when the diet is unbalanced, the need for it increases. Most often, magnesium deficiency occurs during pregnancy, with increased mental stress, stress. The use of the drug allows you to fulfill a magnesium deficiency, has a positive effect on bones, muscle structure, internal organs and systems. The instructions for the drug indicate that taking Magnesium B6 tablets allows you to provide next action on the body:

• maintains cholesterol levels;
• regulates phosphorus metabolism;
• participation in neuromuscular arousal;
• improves the work of the heart muscle;
• takes part in fat, protein and carbohydrate metabolism;
• has a neuroprotective effect;
• synthesizes enzymes;
• stimulates the production of blood cells.

Due to the unique composition of the drug, its intake allows, improves the functioning of the whole organism, eliminates pathological processes, reduce the risk of developing serious diseases.

Indications for use

Indications for the use of the drug are various dysfunctions of the central nervous system, which are manifested against the background of magnesium deficiency in the body.

For adults

• sleep disturbance;
• increased fatigue;
• physical or mental fatigue;
• increased irritability;
• muscle pain and cramps;
• feeling of anxiety.

For kids

For children, Magnesium B6 can be taken from the age of 6 with the following violations:

• increased nervous irritability;
• sleep problems;
• unfounded fears and experiences;
• mental stress;
• acidosis.

Especially useful drug considered for women during pregnancy. Taking the drug allows you to protect the nervous system, to fulfill the deficit useful components... Magnesium is extremely important for a pregnant woman, as its lack can lead to development. The following complaints may be indications for prescribing the drug:

• mood swings;
• increased irritability;
• insomnia;
• increased fatigue;
• severe toxicosis;
• risk of termination of pregnancy;
• cramps of the calf muscles;
• hair loss.

Magnesium can be prescribed at any stage of pregnancy, but its intake must be agreed with the attending physician.

Contraindications

The drug has several contraindications to the appointment:

• intolerance to the components of the drug;
• children under 6 years old;
• intolerance to fructose;
• syndrome of glucose-galactose deficiency.

With caution, the drug should be prescribed for diseases of the kidneys, liver, as well as with other vitamins, especially those that contain a daily dose of magnesium and thiamine. This increases the risk of side effects.

Applications and doses

The instructions for use contain standard doses of the drug, but the doctor must prescribe it individually for each patient.

For adults

The tablets of the drug need to be washed down enough water. The daily dose for an adult is 6 to 8 tablets. The therapeutic course is 30 days.

For kids

Children from 6 years old are prescribed 1 tablet twice a day. The tablets must be swallowed whole, but if it is difficult for the child to swallow the tablet, it can be crushed, mixed with a little water.

For pregnant women and during lactation

During pregnancy daily dose the drug should not exceed 4 - 6 tablets. The dose should be determined by the doctor based on general condition pregnant woman.

Side effects

Magnesium B6 is well tolerated, but in a number of exceptions after taking the medication, adverse reactions organism:

• skin rashes;
• bronchospasm;
• nausea;
• abdominal pain;
• upset stool;

Adverse reactions after taking the drug are very rare, but nevertheless, if they develop, you need to stop taking the drug as soon as possible, consult a doctor. The doctor will be able to stop taking the drug or reduce the dose of the drug.

Interaction with other medicinal products

Reception of Magne B6 reduces the absorption of tetracycline antibiotics, therefore, when taking them, the interval should be at least 3 hours.

special instructions

• Take the drug with caution, since the outer shell of the tablet contains sucrose.
• The tablets are intended only for adults and children from 6 years old.
• Before taking the medicine, you should read the instructions for use.
• Children under 6 years of age are advised to take other forms of the drug: injections, suspension.
• It is forbidden to exceed the daily dose of the drug.
• Do not take the drug without preliminary consultation with a doctor.
• If after 2 weeks of taking the medicine there are no positive results from the treatment, inform the doctor.

Overdose

In the practice of doctors, cases of overdose have not been recorded, but it is still important to observe the prescribed doses of the medicine. With an increase in the doses of the medication, disturbances in the work of the stomach may appear, nausea may appear. In some cases, allergic skin reactions may occur.

Storage conditions

Store the drug out of the reach of children, and avoid direct sunlight. You can buy the medicine without a doctor's prescription.

Analogs

Instead of Magnesium B 6, you can use the following medications:

1. is a complete analogue of the drug Magnesium B6. It is produced in tablets that can be used in patients over 6 years old, including during pregnancy. It is undesirable to drink the medicine during lactation.
2. Magnistad is a medicine from the Stada company, which is a complete analogue of Magnesium B6. It is produced in enteric-coated tablets. They can be used to treat patients over 6 years old, including pregnant patients. Magnesium is excreted through the mammary glands, so the medication is not recommended for nursing mothers.
3. Magnesium plus B6 is a complete analogue of the preparation Magnesium B6. The medicine is produced by PJSC "Valenta Pharmaceuticals", Russia. Both drugs are similar to each other, have similar indications and limitations, causing the same adverse reactions.
4. Magnesium Plus is a combined medication containing magnesium carbonate and lactate, cyanocobalamin, folic acid as active ingredients. It is on sale in effervescent tablets... They are allowed to drink to persons who have reached 6 years old, including during the period of gestation.

Drug price

The cost of the drug is 238 rubles on average. Prices range from 107 to 405 rubles.

Every child needs a variety of vitamins and minerals. Most nutrients he gets out. Sometimes it is necessary additional reception of this or that element in the form medical product... In what cases and at what age is it necessary to use Magnesium B6 for children? Let's try to figure it out.

The importance of magnesium for health

Magnesium is a vital substance for humans. He is one of the seven most necessary for the body minerals along with calcium and phosphorus. Contained in the blood and all cells, and maximum concentration is noted in teeth and bone tissues. Magnesium is involved in huge amount metabolic processes.

It is very important to maintain a sufficient level of this element in children. Magnesium deficiency is associated with the occurrence of a large number diseases of the nervous and cardiovascular system.

The main functions of magnesium:

• conduction of nerve impulses
• contractions of the muscles of the heart and intestines
• normalizes the state of the nervous system
• decrease in intracranial pressure
• stimulation of insulin production
• acceleration of metabolism
• bone formation
• regulation of enzyme activity

In children, the lack of such a mineral is due to its low intake with food and frequent stressful situations. can have many reasons: adaptation to new conditions, the beginning of attending kindergarten or school, family discord, moving, age changes, hormonal changes. All this does not pass without leaving a trace and results in repeated tantrums, tearfulness, anxiety attacks and restless sleep.

Magnesium B6 for children is often used necessary drug... Its peculiarity is that it contains organic magnesium salts. They are absorbed much better (35-50%), while the absorption of inorganic salts is only 5 to 20%. Additionally, the preparation is enriched with vitamin B6, which promotes more efficient absorption of the mineral by the intestines and penetration into the cells of the body.

Having replenished the magnesium deficiency in a child, parents notice better academic performance,. The behavior of children becomes calmer and attention is increased.

The main thing is to observe the measure and not to give medications without reason and agreement with the pediatrician.

Magnesium deficiency symptoms in children

According to research, in modern world about 33% of people suffer from magnesium deficiency. Even from food, only 30-50% is absorbed. The absorption of the element is impaired by the consumption of large quantities of animal fats, diuretics, calcium, soda, sausages. Children also experience decreased absorption of magnesium due to prolonged or prolonged bouts of vomiting.

Magnesium deficiency affects general well-being, the work of the cardiovascular and nervous system, the symptoms in children are as follows:

• lethargy, fatigue
• headaches, in the region of the heart and abdomen
• nervous tics (twitching of the eyelids), flinching
• deterioration of skin, nails and hair
• arrhythmia, tachycardia
• high or low blood pressure
• meteosensitivity
• reduced
• leg muscle cramps
• irritability, withdrawal, panic attacks, increased excitability
• restless sleep, frequent waking up at night
• memory impairment

It is especially recommended to take Magnesium B6 for children during stressful situations, such as adaptation to kindergarten or a new class, moving. The remedy will help increase the stability of the nervous system when needed. After all, it is not always possible to get the required amount of an element from food.

According to the theory of V.A. Tutelyan, a scientist in, daily need in magnesium in children is as follows:

• up to a year - 30-70 mg
• 1-3 years - 60-150 mg
• 4-6 years - 200 mg
• 7-10 years old - 250 mg
• from 10 years - 300 mg

Some of the symptoms of magnesium deficiency may be noticed immediately by parents in their child. In more detail about what the body is threatened by a lack of magnesium can be seen in the video:

However, don't jump to conclusions and panic. A qualified specialist will help dispel doubts and prescribe treatment.

How and in what dosage to give Mania B6 to children

Naturally, if parents have a question: at what age can Magnesium B6 be used for children? The annotation to the drug indicates that the drug in the form of a solution can be given from a year, and in tablets - from 6 years at all. This age limitation is due to the lack of clinical trials.

In practice, neurologists often prescribe this drug to young patients in the first year of life and note positive results treatment. For such babies, a medication should be prescribed exclusively according to indications.

The dosage of the drug is determined based on the magnitude of the magnesium deficiency in the body. So, children over one year old and who have gained 10 kg of weight or more are prescribed Magnesium B6 in the form of a solution from 1 to 4 ampoules per day. Each such ampoule contains 100 mg of the mineral. The tablets are recommended for children from 6 years old and who have gained 20 kg of weight. The dosage is 4 to 6 tablets daily.

The course of treatment usually takes 1 month. If necessary, the treatment is repeated after 3-6 months.

• the daily dose should be evenly distributed over 2-3 doses
• Magnesium B6 should be given in the morning and lunchtime, no later than 4 pm
• you can not drink the medicine with milk
• should not be given simultaneously with calcium and phosphate preparations

Every mom wants the best for her baby. But do not forget that you cannot prescribe medications on your own. This is especially true for young children.

If you take Magnesium B6, you should inform your doctor about it, as the drug passes into milk.

Contraindications and caution

Magnesium B6 has some contraindications:

• serious failure
• fructose intolerance and sucrase-isomaltase deficiency (tablets contain sucrose)
• individual intolerance to components
• glucose-galactose malabsorption (impaired absorption of carbohydrates)
• taking levodopa
• phenylketonuria (violation of amino acid metabolism)

In most cases, the drug is well tolerated by children. Mostly Negative consequences occur in cases of overdose, especially if the child has problems with kidney function.

Overdose symptoms may be as follows:

• low pressure
• diarrhea and vomiting
• confusion
• breathing disorder
• decreased urination
• slowness, decreased activity

With any pharmacological agent an inexperienced person needs to be careful. The most common cases of magnesium overdose are noted just when it is self-administered by parents. Therefore, experts strongly advise against taking any medication "just in case." A doctor should diagnose a magnesium deficiency and prescribe the required dose.

Composition Active ingredients:

• magnesium lactate dihydrate * - 186 mg;
• magnesium pidolate * - 936 mg;
• pyridoxine hydrochloride - 10 mg;

Excipients:

• sodium disulfite - 15 mg,
• sodium saccharinate - 15 mg,
• cherry-caramel flavor - 0.3 ml,
• purified water up to 10 ml.

* - equivalent to the total content of magnesium (Mg ++) 100 mg.

Description Clear liquid Brown color with the smell of caramel.

Pharmacological properties

Pharmacodynamics

Magnesium is vital important element, which is found in all tissues of the body and is necessary for the normal functioning of cells, is involved in most metabolic reactions. In particular, it is involved in the regulation of the transmission of nerve impulses and in muscle contraction. The body gets magnesium from food. Lack of magnesium in the body can be observed in violation of the diet (diet) or with an increase in the need for magnesium (with increased physical and mental stress, stress, pregnancy, use of diuretics).

Pyridoxine (vitamin B6) is involved in many metabolic processes, in the regulation of the metabolism of the nervous system. Vitamin B6 improves the absorption of magnesium from the gastrointestinal intestinal tract and its penetration into cells.

Serum magnesium levels:

• from 12 to 17 mg / l (0.5 - 0.7 mmol / l) - moderate magnesium deficiency;
• below 12 mg / l (0.5 mmol / l) - severe magnesium deficiency.

Pharmacokinetics

Absorption of magnesium in the gastrointestinal tract is no more than 50% of the oral dose. 99% of the magnesium in the body is found inside cells. Approximately 2/3 of intracellular magnesium is distributed to bone tissue, 1/3 is found in smooth and striated muscle tissue. Magnesium is excreted mainly in the urine (at least 1/3 of the dose of magnesium taken).

Indications for use

Indications for use

Identified magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as:

• increased irritability
• minor sleep disturbances,
• gastrointestinal cramps
• cardiopalmus,
• increased fatigue,
• pain and muscle spasms,
• tingling sensation in the muscles.

Contraindications

Contraindications

• Increased sensitivity to the components of the drug.
• Severe renal failure (creatinine clearance less than 30 ml / minute).
• Childhood up to 1 year.
• Simultaneous reception levodopa (see the section "Interaction with other medicines»).

Carefully

• With a moderate degree renal failure, since there is a risk of developing hypermagnesemia.

Application during pregnancy and lactation

Pregnancy

Breastfeeding period

Magnesium penetrates into breast milk... Avoid using the drug during lactation and breastfeeding.

Method of administration and dosage

Method of administration and dosage

Before taking the drug, you should consult your doctor.

The drug can be used for children from 1 year old.

For children over 1 year old (body weight over 10 kg), the daily dose is 10-30 mg magnesium / kg body weight (0.4-1.2 mmol magnesium / kg) or 1-4 ampoules.

The daily dose should be divided into 2-3 doses, taken with meals.

The solution from ampoules is dissolved in ½ glass of water before taking.

Treatment should be discontinued immediately after the normalization of the concentration of magnesium in the blood.

ATTENTION

Ampoules with Magne B6 ® do not require the use of a nail file. To open the ampoule, take it by the tip, having previously covered it with a piece of cloth, and break it off with a sharp movement, first from one pointed end, and then from the other, after directing the first open end of the ampoule at an angle into a glass of water, so that the second the tip of the ampoule was not over the glass. After breaking off the second tip of the ampoule, its contents will freely pour into the glass.

Side effect

Side effect

According to the World Health Organization (WHO), unwanted effects are classified according to their frequency of development as follows: very often (≥ 1/10), often (≥1 / 100,

Violations from the outside immune system:

Very rarely: allergic reactions... Frequency not known: skin reactions (urticaria, itching), severe allergic reactions, including bronchospasm

Gastrointestinal disorders:

Frequency unknown: diarrhea, abdominal pain.

Overdose

Overdose

Symptoms

With normal kidney function, an overdose of magnesium when taken by mouth usually does not lead to toxic reactions... However, in the case of renal failure, magnesium poisoning may develop.

Overdose symptoms, the severity of which depends on the concentration of magnesium in the blood: blood pressure; nausea, vomiting; depression of the central nervous system, decreased reflexes; changes in the electrocardiogram; respiratory depression, coma, cardiac arrest and respiratory paralysis; anuric syndrome.

Treatment

Rehydration, forced diuresis. Renal failure requires hemodialysis or peritoneal dialysis.

Interaction with other medicinal products

Interaction with other medicinal products

Contraindicated combinations

• With levodopa: the activity of levodopa is inhibited by pyridoxine (if the administration of this drug is not combined with the administration of peripheral decarboxylase inhibitors of aromatic L-amino acids). Any amount of pyridoxine should be avoided unless levodopa is taken in combination with aromatic L-amino acid peripheral decarboxylase inhibitors.

• The simultaneous use of drugs containing phosphates or calcium salts can impair the absorption of magnesium in the intestine.

Combinations to be taken into account

• When prescribing tetracyclines by mouth, it is necessary to observe an interval of at least three hours between ingestion of tetracycline and Magne B6, since magnesium preparations reduce the absorption of tetracyclines.

special instructions

special instructions

In the case of severe magnesium deficiency or malabsorption syndrome, treatment begins with intravenous administration magnesium preparations.

In case of concomitant calcium deficiency, it is recommended to correct the magnesium deficiency before starting calcium supplementation or food additives containing calcium.

With frequent use of laxatives, alcohol, strenuous physical and mental stress, the need for magnesium increases, which can lead to the development of magnesium deficiency in the body.

The oral solution contains sulfite, which can cause or exacerbate the manifestations of allergic reactions, including anaphylactic reactions, especially in at-risk patients.

When pyridoxine is used in high doses (more than 200 mg per day) for a long time (over several months or, in some cases, years), sensory axonal neuropathy may develop, which is accompanied by symptoms such as numbness, impaired proprioceptive sensitivity, and distal tremor limbs and gradually developing sensory ataxia (impaired coordination of movements). These abnormalities are usually reversible and go away after you stop taking vitamin B6.

For the body to function correctly, it is simply necessary that it be provided with all vitamins and minerals, and in proper quantities. Dangerous is both the state of a lack of one or another component, and its excess, so this issue must be approached very carefully and wisely. Many elements are absorbed and act more effectively in certain combinations, on the basis of which many drugs are created. For the work of the heart, a complex of vitamin B6 and magnesium is simply irreplaceable, which are combined in one preparation for ease of use. All details of its application and an overview of the main manufacturers will be discussed in this article.

The benefits of magnesium B6 for the body

The drug magnesium-B6 very quickly and effectively improves the condition of the body due to its numerous useful properties... Magnesium as a mineral has the following types of effects on the human body:

• lack of magnesium - common reason the occurrence of heart disease, since this mineral is simply necessary for the correct functioning of the heart muscle;
• regulates metabolic processes;
• normalizes the processes of transmission of nerve impulses;
• helps prevent the development of atherosclerosis;
• minimizes the risks of complications in diabetes;
• with a magnesium deficiency, increased irritability and anxiety may occur, so taking
• a similar drug helps to keep nervous tension under control.

Vitamin B6, which is part of the drug, is intended to enhance the function of the drug - it promotes more efficient absorption of the component from digestive system and its penetration into cellular elements. In addition, this vitamin also has a positive effect on the nervous system and metabolic processes. In general, this drug is simply irreplaceable in a number of diseases and pathological conditions.

Magne-B6 release form

Magne-B6 is available in two pharmacological forms:

• a liquid solution in ampoules, which has a brownish color with a characteristic caramel aroma, which must be taken internally;
• tablets in different options packs (30 and 50 pieces), there are also effervescent tablets.

For convenience, ampoules with a substance usually do not need to be filed with anything, since they are self-breaking - you just need to firmly grasp the thin tip and gently push it over the glass - so the contents of the ampoule will get into the glass without any difficulties.

It should be noted that the contents of one ampoule is equivalent to 100 mg of magnesium, and one tablet is on average about 50 mg, which causes different volumes of drug intake, depending on the selected pharmacological form.

Why magnesium B6 is prescribed: indications for use

The drug Magnesium-B6 is prescribed for admission in the event that there is a shortage of this element in the body, as well as to eliminate those problems that were provoked by this deficiency. Thus, the following problems are considered indications for admission:

• increased nervous irritability;
• irritability;
• anxiety attacks;
• intermittent tingling sensation in the body;
• severe fatigue;
• the presence of spasmodic pain in the muscles;
• cardiopalmus.

For kids

The drug in tablet form can be given to children from 6 years old, and in the form of a solution - from a year. How much substance will be assigned to the baby depends on his condition and the magnitude of the existing deficiency of the component in the body. It should be borne in mind that giving such an additive to children can only be done after the permission of the doctor.

During pregnancy

If a woman has heart problems, then while carrying a baby, she just needs to take magnesium preparations to maintain and stabilize her condition. Also in such delicate time magnesium B6 can be prescribed by a doctor when increased tone uterus and cramps, as such conditions threaten the baby, and magnesium helps to relieve muscle tension.

For men

B-group vitamins and magnesium preparations are very useful for a strong half of humanity. Taking magnesium B6 helps not only to normalize energy metabolism, but also to improve the nervous system, prevent the development of many dangerous processes in the liver and increase the level of testosterone production.

Instructions for use and dosage

To avoid the appearance side effects and achievements maximum benefit from taking the described drug, it is extremely important to strictly follow all the recommendations given by the manufacturer in the instructions. Of particular importance is the dosage in relation to the age of the patient.

How to take pills correctly

Taking pills is best done with meals or immediately after the next meal and you need to drink them with plenty of liquid (best of all - pure water). Depending on what kind of production the drug is used, there can be from one to three receptions during the day.

Consider the standard dosage of Magnesium B6:

• adults (including children over twelve years of age) with a deficiency are prescribed from 6 to 8 tablets, and to eliminate spasms - 4-5 pieces;
• the tablet form is possible for use by children over 6 years old, and the standard dosage is from 2 to 5 tablets per day, depending on the severity of the condition.

The average course of drug treatment is usually a month.

How to dilute the product in ampoules and drink the solution

To prepare the solution, one ampoule of the substance should be diluted in half a glass. warm water... This mixture must be drunk with meals - the number of doses of the drug per day depends on age and body weight. So, for example, for an adult, the optimal volumes are 3-4 ampoules during the day. For children over one year of age, with a body weight not exceeding 10 kilograms, the optimal dose will be from one to three ampoules. Average general course treatment measures is about one month.

Review of the best preparations containing magnesium and vitamin B6

The combination of magnesium and vitamin B6 is very effective in a number of cases, therefore it is often prescribed for admission. There is the most famous drug in this group - this is Magne-B6, but in addition to it there are a number of analogues that will cost less, but provide similar action: Magnelis B6, biodegradable active additive from Blagomax, etc. We suggest that you familiarize yourself with the list the best drugs, based on the action of a powerful combination of pyridoxine and magnesium.

Magne B6 Forte

The tabletted product has the form of biconvex coated tablets. If you break one of them, then two layers will be clearly visible at the break - the white shell and the mass itself active substance inside. No additional active substances not included in the composition, and several auxiliary ones are designed to ensure storage conditions and comfortable reception by patients and have no effect. These pills are usually prescribed for children over 6 years of age and adults for a monthly course, but these criteria may vary depending on the specific situation.

Evalar

The drug from Evalar is a combined complex. The action of which is based on a combination of B6 and magnesium salt, which has the greatest bioavailability. For achievement daily allowance an adult needs to take 6 tablets (2 tablets three times a day, which provides about 70% of the body's needs, the remainder is covered by the food consumed). The product is produced in large purple packages in two versions - 36 or 60 tablets each. It is worth noting that the need to take a sufficiently large number of tablets during the day makes it advisable to purchase a large package.

Antistress

The Antistress complex contains B-group vitamins and minerals, including magnesium. Taking the drug helps to inhibit the processes of nervous excitement, thereby reducing the degree of a person's susceptibility to external influences... The drug is produced in France, which makes it quite high cost compared with Russian counterparts... It is produced in packs of 60 tablets, in one blister - 15 pieces. The drug can be used even for children infancy if necessary, but only in the form of a solution.

Vitamins Doppelherz aktiv (Doppelherz active)

A complex from Doppelherz called Magnesium B6 contains the following active ingredients among the ingredients:

• vitamin B6;
• magnesium;
• folic acid.

They use it as an additional source of vitamins, magnesium and folic acid, which allows you to create normal conditions for the functioning of the body. Taking pills is very simple - just one tablet a day during and after a meal, preferably in the morning for better assimilation... In one package it offers 30 tablets, which are packed in blisters of 10 pieces.

Harm and side effects of the drug

Compliance with the recommendations described in the instructions for the drug reduces the likelihood of side effects to a minimum. Under certain circumstances, they can nevertheless arise, and manifest as a short-term disorder of the digestive system (constipation, active gas formation, nausea, in rare cases - loose stools) or as symptoms of allergies with intolerance to certain components of the product used.

An overdose of magnesium as a component is a difficult situation to come to, since its excess is usually easily excreted by the kidneys. However, if this drug is used by a person with renal failure, then a number of toxic reactions may occur:

• a noticeable decrease in the reflex activity of the body;
• feeling of nausea and vomiting;
• general depression of the psychological state;
• lowering pressure;
• violation of respiratory function;
• in difficult cases, cardiac arrest or coma.

Contraindications

There are a number of situations in which the use of of this drug is prohibited. These include the following pathological conditions and diseases:

• failure of kidney function;
• hypersensitivity to components;
• diabetes (in the event that sucrose is included in the excipients of the tablets);
• the period of taking laxatives;
• increased physical activity;
• abuse of alcoholic beverages.

Separately, it should be noted that during pregnancy, magnesium-B6 is often prescribed to women to normalize their condition, since it does not have any adverse effects. But with breastfeeding it is better to refuse such a drug, since it penetrates into breast milk and can cause an excess of certain substances in the baby's body.

Analogues of the drug Magne-B6

The combination of magnesium and vitamin B6, due to its effectiveness, is quite popular, so find a substitute with more affordable price or a convenient dosage is not difficult. It is worth paying attention to such drugs:

• Magwith;
• Beres Magnesium Plus;
• Magnefar B6;
• Magnelis B6;
• Magnikum, etc.

The key to a successful admission result similar drugs- this is the presence of specific indications and strict adherence to the rules of admission and dosages.

(pyridoxine hydrochloride) - 5 mg.

Heavy kaolin, carboxypolymethylene, sucrose, magnesium in the form of hydrosilicate (talc) and stearate, acacia gum are used as auxiliary components.

Shell composition pills: acacia gum, sucrose, titanium dioxide, trace amounts of hydrous magnesium silicate and carnauba wax in powder form.

Part solution for oral administration, 186 mg of magnesium lactate dihydrate and 936 mg of magnesium pidolate (which corresponds to the total Mg ++ content of 100 mg), 10 mg of pyridoxine hydrochloride are included.

Auxiliary components: sodium disulfite and saccharinate, cherry and caramel flavor, purified water.

Composition pills Magnesium B6 Forte (Antistress): 618.43 mg magnesium citrate, 10 mg pyridoxine hydrochloride, anhydrous lactose, magnesium stearate and hydrosilicate, macrogol 6000, hypromellose, titanium dioxide.

Release form

Pharmacological forms of the drug:

• biconvex oval pills in a white film shell with a shiny smooth surface (10 pieces in blisters of aluminum foil and PVC, 5 blisters per pack);
• clear, brown solution for oral administration with a pronounced caramel smell (in 10 ml ampoules, 10 ampoules in a cardboard packing insert);
• white oval biconvex pills in a film sheath (15 pieces in blisters made of aluminum foil and PVC-PE-PVDC, 2 or 4 blisters per pack).

pharmachologic effect

Pharmacotherapeutic group: B vitamins in combination with minerals... The action of the drug is aimed at replenishing the magnesium deficiency.

Pharmacodynamics and pharmacokinetics

Magnesium (Mg) Is an important biogenic element, which is present in significant quantities in all tissues of the body, is a cofactor of most metabolic processes and ensures the normal functioning of cells.

In particular, this element is necessary for biotransformation creatine phosphate in ATP - nucleoside triphosphate, which plays the role of a universal supplier of energy in living cells of the body.

Cannot be synthesized normally without magnesium protein ... The element takes part in muscle contraction (including supporting normal function heart muscle ), regulates the transmission of pulses to nerve fibers , promotes the expansion vessels , stimulates bile separation , increases motor activity intestinal tract , which in turn promotes excretion from the body.

Magnesium enters the body with food. Its deficiency can be primary (due to hereditary pathologies) or secondary. Secondary magnesium deficiency is usually associated with:

• with a violation of the diet (poor vitamins and minerals diet, exclusively parenteral nutrition, chronic alcoholism);
• with an increase in a person's need for a trace element during intense physical or mental activity, during periods of intense growth, during pregnancy, during stress, excessive loss of Mg through the kidneys (for example, with chronic , abuse diuretics , treatment);
• with impaired absorption of Mg in the gastrointestinal tract due to Ghypoparathyroidism , chronic diarrhea etc..

Vitamin B6 (pyridoxine) improves the course of metabolic processes, including in the brain tissues. As a result, the efficiency of the brain increases, mood and memory improve.

In addition, the presence pyridoxine in the composition of the Magne B 6 preparation allows to improve the absorption of Mg from digestive tract and its distribution in the cells of the body.

If the serum Mg concentration is in the range of 12 to 17 mg / L, it is said to be moderately deficient in Mg. An indicator not exceeding 12 mg / l is evidence of a severe micronutrient deficiency.

V digestive tract not more than half of the ingested dose of Mg is absorbed. 99% of the trace element is located in the intracellular space, while about 66% of the intracellular Mg is distributed in bone tissue , the remaining amount - in striated and smooth muscles .

Mg is excreted mainly in the urine (about a third of the dose of the substance taken).

Indications for use

The indication for the use of Magne B6 is confirmed Mg deficiency (both isolated and associated with other deficiency conditions).

Symptoms of insufficient intake of Mg are increased fatigue and irritability, sleep disturbances, heart palpitations, stomach and intestinal cramps, tingling sensations in the muscles, as well as their spasticity and soreness.

Contraindications

Contraindications to the use of Magne b6 are:

• severe renal failure (conditions in which the clearance does not exceed 30 ml per minute);
• impaired absorption of glucose and galactose , fructose intolerance, sucrose-isomaltase deficiency (only for the tablet form of the drug);
• simultaneous reception antiparkinsonian drug ;
• hypersensitivity to substances contained in tablets / solution.

In pediatrics, tablet forms of the drug are prescribed from the age of six, the solution in ampoules is allowed from the year.

Due to the risk of developing hypermagnesemia care should be taken to prescribe the drug to persons with moderate degree renal failure .

Side effects

The drug very rarely causes the development of side effects. No more than in 0.01% of cases, allergic (including skin) reactions are possible.

Sometimes taking Magne B 6 is accompanied by side effects from digestive tract (flatulence, abdominal pain, diarrhea, nausea, vomiting), however, it is impossible to establish the frequency of their occurrence from the data available to date.

Instruction on Magna B6

Before taking Magne B6, you should consult your doctor. The average course duration is one month. The treatment is stopped immediately after it is possible to normalize the values ​​of the concentration of Mg in the blood.

The medicine is taken with meals 2 or 3 times a day.

If the drug is prescribed during pregnancy, the dose is selected by the attending physician individually.

Magne B6 tablets: instructions for use

Magne b6 tablets are taken 6-8 pieces per day.

According to the instructions for use for children, the daily dose for patients over 6 years old (provided that their body weight exceeds 20 kg) is from 4 to 6 tablets.

Instructions for Magna B6 in ampoules

For adults, the solution is prescribed to take 3-4 ampoules of 10 ml per day. Before taking the drug, dissolve in 0.5 glass of drinking water.

For children over 12 months old (if their body weight exceeds 10 kg) Magne B6 in ampoules is prescribed to take 10-30 mg of Mg per kilogram of weight (the indicated dose is contained in 1-4 ampoules of the drug).

Instruction on Magna B6 Premium

The tablets are taken with meals. Swallow them whole with a glass of drinking water.

For an adult, the daily dose of Magne B 6 is 3-4 tablets. Children over six years old (if their weight exceeds 20 kg) should be given from 10 to 30 mg / kg / day. (or 2-4 tablets).

Overdose

In patients with normally functioning kidneys, magnesium overdose with oral administration usually does not provoke toxic reactions. At renal failure excess magnesium can cause poisoning, the symptoms of which are:

• nausea;
• vomit;
• ECG changes;
• decrease in blood pressure;
• hyporeflexia ;
• depression of the central nervous system;
• disorders of cardio-respiratory function (up to coma, respiratory paralysis and cardiac arrest);
• anuric syndrome .

The severity of overdose symptoms depends on the concentration of the trace element in the blood.

Treatment involves forced diuresis and appointment rehydration therapy ... At renal failure showing peritoneal dialysis and .

Interaction

Due to the fact that pyridoxine (in any amount) inhibits activity levodopa , it is contraindicated to prescribe this drug in combination with Magne B6. This applies to situations where the reception levodopa does not combine with the intake of drugs that suppress the activity of peripheral decarboxylase of aromatic amino acids existing in the L-form.

Since Mg preparations reduce absorption tetracyclines , between taking them, you should maintain at least a three-hour interval.

Terms of sale

Over the counter.

Storage conditions

Magne B6 No. 50: in a place protected from moisture and light, out of reach of children, where the temperature is maintained up to 25 degrees Celsius.

Solution: in a dark place at temperatures up to 25 degrees Celsius.

Magne B6 Forte: at temperatures up to 30 degrees Celsius. Keep out of the reach of children.

Shelf life

The tablets are usable within 24 months, and the solution within 36 months after the date of manufacture.

special instructions

Ampoules with Magne B6 solution are self-breaking (each has 2 marking rings and a break line) and does not require the use of a file.

To open the ampoule, take it by the tip, having previously covered it with a piece of tissue, and with a sharp movement break it off first from the pointed end, then from the opposite one. Opened first the end is directed at an angle into a cup of water so that the tip of the ampoule, which is broken off by the second, is not over the cup.

After the second tip of the ampoule is broken off, the solution will freely pour into the glass.

Patients with need to remember that in the composition of film-coated tablets as excipient sucrose is present. Therefore, it is more preferable for them dosage form is a solution that does not contain sugar.

At malabsorption syndrome (malabsorption) and severe magnesium deficiency, treatment should be started with intravenous administration of Mg preparations.

If a patient is found to have a concomitant calcium deficiency, the Mg deficiency is corrected before taking dietary supplements or drugs that contain Ca.

The solution contains sulfite, a substance that can cause or enhance the severity of hypersensitivity reactions, including anaphylactic reactions (especially in patients at risk).

Taking high (exceeding 200 mg / day) doses pyridoxine within a few months / years can cause development sensory axonal polyneuropathy , which manifests itself with symptoms such as tremors, numbness and disorders of proprioceptive sensitivity of the distal parts of the arms and legs, gradually manifesting sensory ataxia (imbalance).

Disorders of this kind are usually reversible and disappear after stopping the intake of vitamins.

Analogs of Magne B6

Matching ATX level 4 code:

Magne B6 analogs are drugs Magnesium B6 Evalar , Magnelis B6 , , Magnistad , AT 6 , Beres Magnesium plus B6 .

The price of tablet analogues is from 150 Russian rubles.

Which is better: Magnelis or Magne B6?

A drug Magnelis B6 is produced by Pharmstandard and, like its analogue Magne B6, is intended to replenish deficiency of Mg in organism. The products have a similar composition (Magnelis contains 470 mg of Mg lactate and 5 mg pyridoxine , in Magna B6 - 470 mg of Mg lactate dihydrate and 5 mg pyridoxine ), the same indications for use and contraindications, cause similar side effects.

The main differences are manufacturer and price.

Magne B6 for children

Magnesium is very important for children, as it participates in various biochemical reactions of the body, improves the absorption of calcium and the tone of the walls of blood vessels, and normalizes the conduction of nerve impulses in the brain.

Magnesium deficiency is very closely related to stress. Experts consider Mg deficiency and stress to be interdependent processes that can aggravate each other.

AND spicy , and chronic stress lead to depletion of the intracellular pool of Mg and its losses in the urine. This is due to the fact that in stressful situation the body secretes more and, which contribute to the elimination of Mg from cells.

Magnesium deficiency often leads to a decrease in the ability to concentrate, memory impairment, seizures , impaired consciousness and the coordinating sphere (usually this manifests itself in the form nystagmus, ataxia, tremor ). Some children develop paresthesias and rising tendon reflexes .

In children of all ages, a lack of Mg (like stress) provokes an increase in - one of the most significant components of stress and changes the cerebroreactive reactivity of blood vessels towards a constrictor response.

Biochemical and clinical neuropsychological studies, as well as reviews about Magna B6 for children, confirm that taking Mg preparations allows you to restrain the increase in blood pressure, increase stress resistance, improve behavior, memory and attention, normalize sleep, reduce anxiety, level synkinesis and aggression.

In accordance with the instructions, in pediatric practice, the solution is prescribed from the age of one, tablets - after 6 years, however, in the presence of neurological disorders, Magne B6 can be used from the first days of life. Dosage infant calculated depending on his body weight.

It is very important that the composition of the preparation (both in the form of a solution and in the form of tablets) contains organic Mg salts - lactate, citrate and pidolate - which are characterized by high bioavailability and practically do not cause side effects.

Magne B6 Forte, which is based on Mg citrate, is recommended for use in children with oxalaturia and acidosis , as well as in children with a shift to the side: the agent is used to compensate for rapid nervous and mental exhaustion in patients with neuroarthritic type of constitution and for prevention urolithiasis .

Magne B6 during pregnancy

Why Magne B6 during pregnancy?

Magne b6 is prescribed quite often during pregnancy. The use of the drug in pregnant women is advisable when:

• threatening spontaneous miscarriage hypertonicity of the muscles of the uterus ;
• confirmed by test results deficiency of Mg in organism.

Clinical experience with the use of Mg preparations and doctors' reviews about Magna B6 indicate that the appointment of a remedy for hypertonicity of the uterus allows you to quickly and effectively calm the nervous system, as well as relieve spasm and muscle tension.

The main reason for the increase in the tone of the muscles of the uterus is the calcium contained in the muscle fibers. Mg, on the other hand, has the ability to reduce its amount and thus promotes muscle relaxation.

During the period of bearing a child female body requires more magnesium than usual. If a trace element does not enter it from the outside in the required doses, the fetus begins to draw Mg from the mother's body, which significantly affects the health and well-being of the pregnant woman. After the mother's Mg stores are depleted, the fetus will also begin to deteriorate.

Magnesium deficiency is the cause of poor development of blood vessels in the placenta, and this leads to malnutrition of the fetus and the emergence of a threat of miscarriage.

Contraindications

The instructions for the drug indicate that contraindications to its use are fructose intolerance , severe renal failure , allergic reactions to substances contained in tablets / solution.

How to take MagneB6 during pregnancy?

The dosage of Magne B6 during pregnancy is usually as follows: 2 tablets with each of the main meals (morning, lunch and evening). Thus, the dose of Magne B 6 for a pregnant woman is 6 tablets per day, and the dosage regimen does not change depending on the duration of pregnancy.

In the 1st and 2nd trimesters, the use of the drug is advisable if there is a threat of miscarriage. In the third trimester, a woman usually has an increase in discomfort, night cramps and swelling appear.

Magnesium deficiency can lead to increased secretion aldosterone and the development of edema. A delay in the elimination of fluid from the body, in turn, provokes increased blood pressure , which is very dangerous both during pregnancy and during delivery.

The duration of treatment can range from 2 weeks to 9 months. After childbirth, the drug is stopped, since it tends to penetrate into the milk of a nursing woman.